PMID- 17907284
OWN - NLM
STAT- MEDLINE
DCOM- 20071220
LR  - 20211020
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 13
IP  - 41
DP  - 2007 Nov 7
TI  - Genetic epidemiology of primary sclerosing cholangitis.
PG  - 5421-31
AB  - The aetiology of primary sclerosing cholangitis (PSC) is not known. A more than 
      80-fold increased risk of PSC among first-degree relatives emphasizes the 
      importance of genetic factors. Genetic associations within the human leukocyte 
      antigen (HLA) complex on chromosome 6p21 were detected in PSC 25 years ago. 
      Subsequent studies have substantiated beyond doubt that one or more genetic 
      variants located within this genetic region are important. The true identities of 
      these variants, however, remain to be identified. Several candidate genes at 
      other chromosomal loci have also been investigated. However, according to strict 
      criteria for what may be denominated a susceptibility gene in complex diseases, 
      no such gene exists for PSC today. This review summarises present knowledge on 
      the genetic susceptibility to PSC, as well as genetic associations with disease 
      progression and clinical subsets of particular interest (inflammatory bowel 
      disease and cholangiocarcinoma).
FAU - Karlsen, Tom-H
AU  - Karlsen TH
AD  - Medical Department, Rikshospitalet-Radiumhospitalet Medical Center, N-0027 Oslo, 
      Norway. t.h.karlsen@klinmed.uio.no
FAU - Schrumpf, Erik
AU  - Schrumpf E
FAU - Boberg, Kirsten-Muri
AU  - Boberg KM
LA  - eng
PT  - Editorial
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Bile Duct Neoplasms/genetics/immunology
MH  - Bile Ducts, Intrahepatic/immunology
MH  - Cholangiocarcinoma/genetics/immunology
MH  - Cholangitis, Sclerosing/complications/epidemiology/*genetics/immunology
MH  - *Chromosomes, Human, Pair 6
MH  - Data Interpretation, Statistical
MH  - Disease Progression
MH  - Effect Modifier, Epidemiologic
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Inflammatory Bowel Diseases/genetics/immunology
MH  - Odds Ratio
MH  - Pedigree
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC4171275
EDAT- 2007/10/02 09:00
MHDA- 2007/12/21 09:00
PMCR- 2007/11/07
CRDT- 2007/10/02 09:00
PHST- 2007/10/02 09:00 [pubmed]
PHST- 2007/12/21 09:00 [medline]
PHST- 2007/10/02 09:00 [entrez]
PHST- 2007/11/07 00:00 [pmc-release]
AID - 10.3748/wjg.v13.i41.5421 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2007 Nov 7;13(41):5421-31. doi: 10.3748/wjg.v13.i41.5421.