PMID- 17907962
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20191110
IS  - 1744-7631 (Electronic)
IS  - 1472-8222 (Linking)
VI  - 11
IP  - 10
DP  - 2007 Oct
TI  - Targeting PGC-1 alpha to control energy homeostasis.
PG  - 1329-38
AB  - The prevalence of Type 2 diabetes is increasing at an alarming rate in most parts 
      of the world. Effective therapeutic drugs are urgently needed, not only to 
      control the disease but also to prevent or delay its progression. Therapies that 
      target the underlying pathogenesis could, in theory, hold such potential. Recent 
      evidence strongly suggests that impaired mitochondrial function is part of the 
      underlying pathogenesis of insulin resistance and Type 2 diabetes. Peroxisome 
      proliferator-activated receptor gamma co-activator-1 alpha (PGC-1alpha) is a 
      transcription co-activator that plays a key role in regulating mitochondrial 
      biogenesis and energy metabolism in multiple tissues. Thus, improvement and 
      restoration of mitochondrial function and oxidative capacity through activation 
      of PGC-1alpha could provide new treatments for metabolic diseases. A diverse 
      array of proteins has been shown to regulate PGC-1alpha transcription and/or 
      activity, some of which represent promising targets for pharmaceutical 
      intervention.
FAU - Wu, Zhidan
AU  - Wu Z
AD  - Novartis Institutes for BioMedical Research, Inc., 100 Technology Square, 
      Cambridge, MA 02139, USA. zhidan.wu@novartis.com
FAU - Boss, Olivier
AU  - Boss O
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Ther Targets
JT  - Expert opinion on therapeutic targets
JID - 101127833
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPARGC1A protein, human)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/drug therapy/metabolism
MH  - Drug Delivery Systems/*methods
MH  - Energy Metabolism/drug effects/*physiology
MH  - Heat-Shock Proteins/*metabolism/physiology
MH  - Homeostasis/drug effects/*physiology
MH  - Humans
MH  - Mitochondria/drug effects/metabolism
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Transcription Factors/*metabolism/physiology
RF  - 96
EDAT- 2007/10/03 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/10/03 09:00
PHST- 2007/10/03 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/10/03 09:00 [entrez]
AID - 10.1517/14728222.11.10.1329 [doi]
PST - ppublish
SO  - Expert Opin Ther Targets. 2007 Oct;11(10):1329-38. doi: 
      10.1517/14728222.11.10.1329.