PMID- 17908668
OWN - NLM
STAT- MEDLINE
DCOM- 20071211
LR  - 20161013
IS  - 0929-6646 (Print)
IS  - 0929-6646 (Linking)
VI  - 106
IP  - 9
DP  - 2007 Sep
TI  - Acquisition and cure of autoimmune disease following allogeneic hematopoietic 
      stem cell transplantation.
PG  - 779-83
AB  - Hematopoietic stem cell transplantation (HSCT) can either cause or eliminate 
      autoimmune disease. Here, we report two cases. One was a 33-year-old woman with 
      myelodysplastic syndrome (refractory anemia) who received bone marrow 
      transplantation from her human leukocyte antigen (HLA)-identical sister who had a 
      history of Graves disease. Antithyroid antibodies, including antimicrosomal 
      antibody and antithyroglobulin antibody, appeared 4 months after transplantation. 
      Clinical hyperthyroidism appeared 7 months after transplantation, and a 
      hypothyroid state was noted 2 months later. The other case was a 50-year-old 
      woman with Sjgrens syndrome and hypothyroidism who was diagnosed with peripheral 
      T cell non-Hodgkins lymphoma. She received allogeneic peripheral blood stem cell 
      transplantation (PBSCT) from her histocompatible sister owing to only partial 
      response to traditional chemotherapy. Cure of lymphoma and remission of Sjgrens 
      syndrome was noted 4 years after PBSCT. These two illustrative cases, one of 
      acquisition of hyperthyroidism and the other of remission of Sjgrens syndrome 
      after transplantation, highlights that HSCT can induce adoptive autoimmune 
      disease or cure coincidental autoimmune disease. Donor selection and attentive 
      monitoring is required in such circumstances.
FAU - Hou, Hsin-An
AU  - Hou HA
AD  - Division of Hematology, Department of Internal Medicine, National Taiwan 
      University Hospital, College of Medicine, National Taiwan University, Taipei, 
      Taiwan.
FAU - Tang, Jih-Luh
AU  - Tang JL
FAU - Hsu, Szu-Chun
AU  - Hsu SC
FAU - Yu, Chia-Li
AU  - Yu CL
FAU - Chen, Yao-Chang
AU  - Chen YC
FAU - Yao, Ming
AU  - Yao M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Singapore
TA  - J Formos Med Assoc
JT  - Journal of the Formosan Medical Association = Taiwan yi zhi
JID - 9214933
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood
MH  - Autoimmune Diseases/*etiology/*therapy
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Hyperthyroidism/etiology
MH  - Hypothyroidism/etiology
MH  - Lymphoma, Non-Hodgkin/therapy
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/therapy
MH  - Thyroid Gland/immunology
MH  - Transplantation, Homologous/adverse effects
EDAT- 2007/10/03 09:00
MHDA- 2007/12/12 09:00
CRDT- 2007/10/03 09:00
PHST- 2007/10/03 09:00 [pubmed]
PHST- 2007/12/12 09:00 [medline]
PHST- 2007/10/03 09:00 [entrez]
AID - S0929-6646(08)60040-6 [pii]
AID - 10.1016/S0929-6646(08)60040-6 [doi]
PST - ppublish
SO  - J Formos Med Assoc. 2007 Sep;106(9):779-83. doi: 10.1016/S0929-6646(08)60040-6.