PMID- 17910739
OWN - NLM
STAT- MEDLINE
DCOM- 20080414
LR  - 20131121
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 13
IP  - 1
DP  - 2008 Mar
TI  - Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute 
      model of MDMA and methamphetamine exposure in rats.
PG  - 15-25
AB  - Club drug abuse is a growing problem in the United States. Beyond addiction and 
      toxicity are endocrine effects which are not well characterized. Specifically, 
      the changes in appetite following exposure to drugs of abuse are an interesting 
      but poorly understood phenomenon. Serum hormones such as leptin, ghrelin, growth 
      hormone (GH), and neuropeptide-Y (NP-Y) are known to affect appetite, but have 
      not been studied extensively with drugs of abuse. In this work, we examine the 
      effects of club drugs 3,4-methylenedioxymethamphetamine (MDMA) (ecstasy) and 
      methamphetamine (METH) (doses of 5, 20 and 40 mg/kg) on serum concentrations of 
      these hormones in adult male Sprague-Dawley rats 6, 12, 24 and 48 hours after 
      drug administration. In a dose-dependent manner, MDMA was shown to cause 
      transient significant decreases in serum leptin and GH followed by a base line 
      recovery after 24 hours. Conversely, serum ghrelin increased and normalized after 
      24 hours. Interestingly, serum NP-Y showed a steady decrease in both treatment of 
      MDMA and METH at different time points and dosages. In humans, abuse of these 
      drugs reduces eating. As evident from these data, acute administration of METH 
      and MDMA had significant effects on different serum hormone levels involved in 
      appetite regulation. Future studies should be performed to see how chronic, low 
      dose drug administration would affect hormone levels and try to answer questions 
      about the physiological mechanisms involved in the anorexic paradigm observed in 
      drug use.
FAU - Kobeissy, Firas H
AU  - Kobeissy FH
AD  - University of Florida College of Medicine, Gainesville, FL 32610, USA. 
      firasko@ufl.edu
FAU - Jeung, Jennifer A
AU  - Jeung JA
FAU - Warren, Matthew W
AU  - Warren MW
FAU - Geier, Jacqueline E
AU  - Geier JE
FAU - Gold, Mark S
AU  - Gold MS
LA  - eng
GR  - T 35 HL07489/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071002
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Ghrelin)
RN  - 0 (Leptin)
RN  - 0 (Neuropeptide Y)
RN  - 44RAL3456C (Methamphetamine)
RN  - 9002-72-6 (Growth Hormone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*toxicity
MH  - Amphetamine-Related Disorders/*blood
MH  - Animals
MH  - Appetite/drug effects
MH  - Body Weight/drug effects
MH  - *Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Ghrelin/*blood
MH  - Growth Hormone/*blood
MH  - Leptin/*blood
MH  - Male
MH  - Methamphetamine/*toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neuropeptide Y/*blood
MH  - Radioimmunoassay
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/10/04 09:00
MHDA- 2008/04/15 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2008/04/15 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - ADB083 [pii]
AID - 10.1111/j.1369-1600.2007.00083.x [doi]
PST - ppublish
SO  - Addict Biol. 2008 Mar;13(1):15-25. doi: 10.1111/j.1369-1600.2007.00083.x. Epub 
      2007 Oct 2.