PMID- 17911044
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20071123
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 125
IP  - 3
DP  - 2007 Dec
TI  - The role of CCL22/macrophage-derived chemokine in allergic rhinitis.
PG  - 291-8
AB  - Dendritic cells (DCs) are considered to be the most powerful antigen-presenting 
      cells (APCs). DCs are thought to be associated with Th1 or Th2 polarization and 
      with polarization-induced disease such as atopic dermatitis, asthma and allergic 
      rhinitis, but its mechanism is not well known. In this study, we analyzed the 
      mRNA expression of DCs between birch pollen allergic rhinitis and healthy 
      controls by using cDNA array. We found that the expressions of 
      CCL22/macrophage-derived chemokine (MDC) differed significantly. We also revealed 
      that CCL22/MDC production was higher in patients than in healthy donors. By 
      chemotaxis assay, CCL22/MDC can enhance the migration of patient's T cells rather 
      than those of healthy controls. Surface marker analysis of migrated cells 
      revealed that the most of migrated cells expressed CCR4, which were considered to 
      be Th2 cells. Furthermore, CD1a(+) CD83(+) cells located in the nasal mucosa 
      expressed CCL22/MDC in vivo. To the best of our knowledge, this is the first 
      report clearly indicating the role of CCL22/MDC in allergic rhinitis.
FAU - Yanai, Mitsuru
AU  - Yanai M
AD  - Department of Pathology, Asahikawa Medical College, Hokkaido, Japan. 
      mitsuru@asahikawa-med.ac.jp
FAU - Sato, Keisuke
AU  - Sato K
FAU - Aoki, Naoko
AU  - Aoki N
FAU - Takiyama, Yumi
AU  - Takiyama Y
FAU - Oikawa, Kensuke
AU  - Oikawa K
FAU - Kobayashi, Hiroya
AU  - Kobayashi H
FAU - Kimura, Shoji
AU  - Kimura S
FAU - Harabuchi, Yasuaki
AU  - Harabuchi Y
FAU - Tateno, Masatoshi
AU  - Tateno M
LA  - eng
PT  - Journal Article
DEP - 20071029
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Antigens, CD)
RN  - 0 (CCR4 protein, human)
RN  - 0 (Chemokine CCL22)
RN  - 0 (Chemokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, CCR4)
SB  - IM
MH  - Antigens, CD/biosynthesis
MH  - Betula/immunology
MH  - Cell Movement/immunology
MH  - Chemokine CCL22/*immunology/metabolism
MH  - Chemokines/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Expression/immunology
MH  - Humans
MH  - Immunohistochemistry
MH  - Nasal Mucosa/cytology/immunology
MH  - Oligonucleotide Array Sequence Analysis
MH  - Pollen/immunology
MH  - RNA, Messenger/analysis
MH  - Receptors, CCR4/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Rhinitis, Allergic, Seasonal/*immunology/metabolism
MH  - T-Lymphocyte Subsets/immunology
MH  - Th2 Cells/*immunology/metabolism
EDAT- 2007/10/04 09:00
MHDA- 2008/01/23 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/01/01 00:00 [received]
PHST- 2007/07/14 00:00 [revised]
PHST- 2007/08/03 00:00 [accepted]
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - S1521-6616(07)01316-2 [pii]
AID - 10.1016/j.clim.2007.08.002 [doi]
PST - ppublish
SO  - Clin Immunol. 2007 Dec;125(3):291-8. doi: 10.1016/j.clim.2007.08.002. Epub 2007 
      Oct 29.