PMID- 17911415
OWN - NLM
STAT- MEDLINE
DCOM- 20071212
LR  - 20071003
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1110
DP  - 2007 Sep
TI  - Immunoglobulin-like transcripts as risk genes for autoimmunity.
PG  - 10-4
AB  - Risk genes for multiple sclerosis (MS) are localized in the gene regions 6p21-11 
      and 19q13, the latter harboring the genes of the immunoglobulin-like transcripts 
      (ILTs). ILTs are a family of activating and inhibitory receptors expressed on 
      antigen-presenting cells (APCs) as well as on natural killer (NK) and T cells. 
      Because of the inhibitory function of ILT2 and ILT4 and their binding to human 
      leukocyte antigen (HLA)-G, they play a role in immune tolerance and may be 
      important in pathogenesis of autoimmunity. ILT6 shows presence-absence 
      variability and is produced by macrophages in a soluble form. ILT6 deletion is 
      associated with MS. Furthermore, ILT6 activates T cell proliferation and is 
      therefore a candidate gene for autoimmune disorders.
FAU - Kabalak, Gamze
AU  - Kabalak G
AD  - Department of Clinical Immunology, Medical School Hannover, Germany. 
      kabalak.gamze@mh-hannover.de
FAU - Koch, Silke
AU  - Koch S
FAU - Dobberstein, Baukje
AU  - Dobberstein B
FAU - The, Yu-Han
AU  - The YH
FAU - Matthias, Torsten
AU  - Matthias T
FAU - Schnarr, Sebastian
AU  - Schnarr S
FAU - Schmidt, Reinhold E
AU  - Schmidt RE
FAU - Witte, Torsten
AU  - Witte T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Autoimmune Diseases/genetics/immunology
MH  - Autoimmunity/*genetics/*immunology
MH  - Humans
MH  - Receptors, Immunologic/*genetics/*immunology
MH  - Risk Factors
MH  - Transcription, Genetic/*genetics/*immunology
EDAT- 2007/10/04 09:00
MHDA- 2007/12/13 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2007/12/13 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - 1110/1/10 [pii]
AID - 10.1196/annals.1423.002 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1110:10-4. doi: 10.1196/annals.1423.002.