PMID- 17911423
OWN - NLM
STAT- MEDLINE
DCOM- 20071212
LR  - 20071003
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1110
DP  - 2007 Sep
TI  - X monosomy in female systemic lupus erythematosus.
PG  - 84-91
AB  - Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, 
      predominantly occurring in women of childbearing age. SLE, like several other 
      autoimmune diseases, is characterized by a striking female predominance and, 
      although sex hormone influences have been suggested as an explanation for this 
      phenomenon, definitive data are still unavailable. Our group recently reported an 
      increased X monosomy in lymphocytes of women, affected with primary biliary 
      cirrhosis (PBC), systemic sclerosis (SSc), and autoimmune thyroiditis (AITD) in 
      comparison to healthy women, thus suggesting the involvement of this chromosome 
      in female predominance and in the deregulation of the immune system that 
      characterizes autoimmunity. We have now evaluated X monosomy rates in SLE using 
      fluorescence in situ hybridization (FISH) on peripheral mononuclear white blood 
      cells (PBMCs) from female patients compared to healthy age-matched controls. In 
      addition, because of a previous finding of microchimerism as a pathogenetic cause 
      of a number of autoimmune diseases, we investigated the presence of cells 
      carrying the Y chromosome. We did not identify an increased X monosomy in women 
      with SLE compared to controls (P = 0.3960, SLE vs. HCs, Student's t-test), thus 
      suggesting that a different mechanism of immune deregulation might be predominant 
      in the female population of patients with SLE.
FAU - Invernizzi, Pietro
AU  - Invernizzi P
AD  - Division of Internal Medicine and Liver Unit, Department of Medicine, Surgery and 
      Dentistry, San Paolo Hospital School of Medicine, University of Milan, Via di 
      Rudini 8, 20142 Milan, Italy. pietro.invernizzi@unimi.it
FAU - Miozzo, Monica
AU  - Miozzo M
FAU - Oertelt-Prigione, Sabine
AU  - Oertelt-Prigione S
FAU - Meroni, Pier Luigi
AU  - Meroni PL
FAU - Persani, Luca
AU  - Persani L
FAU - Selmi, Carlo
AU  - Selmi C
FAU - Battezzati, Pier Maria
AU  - Battezzati PM
FAU - Zuin, Massimo
AU  - Zuin M
FAU - Lucchi, Simona
AU  - Lucchi S
FAU - Marasini, Bianca
AU  - Marasini B
FAU - Zeni, Silvana
AU  - Zeni S
FAU - Watnik, Mitchell
AU  - Watnik M
FAU - Tabano, Silvia
AU  - Tabano S
FAU - Maitz, Silvia
AU  - Maitz S
FAU - Pasini, Simone
AU  - Pasini S
FAU - Gershwin, M Eric
AU  - Gershwin ME
FAU - Podda, Mauro
AU  - Podda M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - Chimerism
MH  - Chromosomes, Human, X/*genetics
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Leukocytes/metabolism
MH  - Lupus Erythematosus, Systemic/diagnosis/*genetics
MH  - Middle Aged
MH  - Monosomy/*genetics
EDAT- 2007/10/04 09:00
MHDA- 2007/12/13 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2007/12/13 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - 1110/1/84 [pii]
AID - 10.1196/annals.1423.010 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1110:84-91. doi: 10.1196/annals.1423.010.