PMID- 17911446 OWN - NLM STAT- MEDLINE DCOM- 20071212 LR - 20071003 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 1110 DP - 2007 Sep TI - Acute ST elevation myocardial infarction during intravenous immunoglobulin infusion. PG - 315-8 AB - Intravenous immunoglobulin (IVIG) preparations are increasingly being used in the treatment of autoimmune disorders. This treatment is regarded as generally safe, and most of the adverse effects associated with IVIG administration are mild and transient. This paper reports a 72-year-old patient with known ischemic heart disease admitted for a Guillain-Barre syndrome variant, who developed acute ST elevation myocardial infarction (MI) during the first hours of IVIG infusion. The literature on acute MI during IVIG treatment is reviewed. Evaluation of each patient for cardiovascular risk prior to IVIG treatment is recommended as is the assessment of risk versus benefit. If IVIG is prescribed, we propose close monitoring and slow infusion rate. FAU - Barsheshet, Alon AU - Barsheshet A AD - Heart Institute, Sheba Medical Center, and Sackler Faculty of Medicine, Tel-Aviv University, Israel. FAU - Marai, Ibrahim AU - Marai I FAU - Appel, Shmulik AU - Appel S FAU - Zimlichman, Eyal AU - Zimlichman E LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Acute Disease MH - Aged MH - Humans MH - Immunoglobulins, Intravenous/administration & dosage/*adverse effects/*therapeutic use MH - Immunotherapy MH - Infusions, Intravenous MH - Male MH - Myocardial Infarction/*chemically induced EDAT- 2007/10/04 09:00 MHDA- 2007/12/13 09:00 CRDT- 2007/10/04 09:00 PHST- 2007/10/04 09:00 [pubmed] PHST- 2007/12/13 09:00 [medline] PHST- 2007/10/04 09:00 [entrez] AID - 1110/1/315 [pii] AID - 10.1196/annals.1423.033 [doi] PST - ppublish SO - Ann N Y Acad Sci. 2007 Sep;1110:315-8. doi: 10.1196/annals.1423.033.