PMID- 17911471
OWN - NLM
STAT- MEDLINE
DCOM- 20071212
LR  - 20071003
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1110
DP  - 2007 Sep
TI  - Suppression of experimental autoimmune myasthenia gravis by intravenous 
      immunoglobulin and isolation of a disease-specific IgG fraction.
PG  - 550-8
AB  - Intravenous immunoglobulin (IVIG) administration has been beneficially used for 
      the treatment of a variety of autoimmune diseases including myasthenia gravis 
      (MG). We have demonstrated that IVIG administration in experimental autoimmune MG 
      (EAMG) results in suppression of disease that is accompanied by decreased Th1 
      cell and B cell proliferation. Chromatography of pooled human immunoglobulins 
      (IVIGs) on immobilized IgG, isolated from rats with EAMG, results in a complete 
      depletion of the suppressive activity of the IVIG. Moreover, the eluate from this 
      EAMG-specific antibody column retains the immunosuppressive activity of IVIG. 
      This study supports the notion that the therapeutic effect of IVIGs is mediated 
      by an antigen-specific anti-immunoglobulin (anti-idiotypic) activity that is 
      essential for its suppressive activity.
FAU - Fuchs, Sara
AU  - Fuchs S
AD  - Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, 
      Israel. sara.fuchs@weizmann.ac.il
FAU - Feferman, Tali
AU  - Feferman T
FAU - Zhu, Kai-Yun
AU  - Zhu KY
FAU - Meidler, Roberto
AU  - Meidler R
FAU - Margalit, Raanan
AU  - Margalit R
FAU - Wang, Ningshan
AU  - Wang N
FAU - Laub, Orgad
AU  - Laub O
FAU - Souroujon, Miriam C
AU  - Souroujon MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunoglobulin G/immunology/*isolation & purification/*therapeutic use
MH  - Immunoglobulins, Intravenous/*immunology/*therapeutic use
MH  - Immunotherapy
MH  - Myasthenia Gravis, Autoimmune, Experimental/*immunology/pathology/*therapy
MH  - Rats
EDAT- 2007/10/04 09:00
MHDA- 2007/12/13 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2007/12/13 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - 1110/1/550 [pii]
AID - 10.1196/annals.1423.059 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1110:550-8. doi: 10.1196/annals.1423.059.