PMID- 17911474
OWN - NLM
STAT- MEDLINE
DCOM- 20071212
LR  - 20220311
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1110
DP  - 2007 Sep
TI  - Effective therapy with anti-TNF-alpha in patients with psoriatic arthritis is 
      associated with decreased levels of metalloproteinases and angiogenic cytokines 
      in the sera and skin lesions.
PG  - 578-89
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays a central role in sustaining the 
      inflammatory process in the skin as well as in the joints of patients with 
      psoriasis and psoriatic arthritis. In fact, biological therapies based on 
      monoclonal antibodies against TNF-alpha have been proven to be effective on both 
      the arthropathy and the cutaneous symptoms of the disease. Among the several 
      effects produced by TNF-alpha on keratinocytes there is the induction of 
      expression of MMP-9, a matrix metalloproteinase (MMP) produced mainly by 
      monocytes and macrophages. In this article we refer to the results of a study on 
      the behavior of MMP-9 in the sera and in the lesional skin in association with 
      effective therapy with infliximab. Measurements of TNF-alpha, MMP-2, vascular 
      endothelial growth factor (VEGF), and E-selectin were also performed in the same 
      samples. Eleven psoriatic patients included in a therapeutic protocol based on 
      the administration of infliximab monotherapy were collected before treatment and 
      after 6 and 12 weeks of therapy. Significant decrease of MMP-9 and MMP-2 levels 
      in the sera was associated with clinical improvement and with the decrease of 
      TNF-alpha, VEGF, and E-selectin, angiogenic molecules already known to be 
      implicated in the clinical expression of psoriasis. The clinical amelioration of 
      the cutaneous expression of psoriasis was significantly associated with the 
      decrease of MMP-9, TNF-alpha, and E-selectin levels, spontaneously released by 
      lesional biopsy samples before and after therapy, measured in the culture 
      supernatants by immunoenzymatic assays. In addition, significant correlations 
      were found between the clinical score and TNF-alpha, MMP-9, and E-selectin 
      lesional production. MMP-9 levels were significantly correlated with those of 
      TNF-alpha. Our findings show the existence of a direct relationship between MMP-9 
      and TNF-alpha production, strongly suggesting that MMP-9 may play a key role in 
      the skin inflammatory process in psoriasis, while a different role may be 
      attributed to MMP-2.
FAU - Cordiali-Fei, Paola
AU  - Cordiali-Fei P
AD  - Clinical Pathology and Microbiology Laboratory, San Gallicano Dermatology 
      Institute, Via Elio Chianesi 53, 00144 Roma, Italy. cordiali-fei@ifo.it
FAU - Trento, Elisabetta
AU  - Trento E
FAU - D'Agosto, Giovanna
AU  - D'Agosto G
FAU - Bordignon, Valentina
AU  - Bordignon V
FAU - Mussi, Anna
AU  - Mussi A
FAU - Ardigo, Marco
AU  - Ardigo M
FAU - Mastroianni, Antonio
AU  - Mastroianni A
FAU - Vento, Antonella
AU  - Vento A
FAU - Solivetti, Francesco
AU  - Solivetti F
FAU - Berardesca, Enzo
AU  - Berardesca E
FAU - Ensoli, Fabrizio
AU  - Ensoli F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.- (Metalloproteases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Psoriatic/*immunology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Metalloproteases/*metabolism
MH  - Middle Aged
MH  - Skin/blood supply/enzymology/immunology
MH  - Tumor Necrosis Factor-alpha/*immunology
EDAT- 2007/10/04 09:00
MHDA- 2007/12/13 09:00
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2007/12/13 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
AID - 1110/1/578 [pii]
AID - 10.1196/annals.1423.062 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Sep;1110:578-89. doi: 10.1196/annals.1423.062.