PMID- 17912701
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20211020
IS  - 1095-6670 (Print)
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 21
IP  - 5
DP  - 2007
TI  - Lead-induced alterations of apoptosis and neurotrophic factor mRNA in the 
      developing rat cortex, hippocampus, and cerebellum.
PG  - 265-72
AB  - Previous reports have recently shown the prototypic neurotoxicant, lead, to 
      induce apoptosis in the brains of developing organisms. In the current study, 
      timed-pregnant rats were exposed to lead acetate (0.2% in the drinking water) 24 
      h following birth at postnatal day 1 (PND 1). Dams and pups were continuously 
      exposed to lead through the drinking water of the dam until PND 20. Postnatal 
      exposure in the pups resulted in altered mRNA levels of the following apoptotic 
      and neurotrophic factors: caspase 2 and 3, bax, bcl-x, brain-derived neurotrophic 
      factor (BDNF). Ribonuclease protection assays were conducted to measure the 
      factors simultaneously at the following postnatal time points: 9, 12, 15, 20, 25, 
      days. Our results suggest a brain region- and time-specific response following 
      lead acetate exposure. The region most vulnerable to alterations occurs in the 
      hippocampus with alterations beginning at PND 12, in which caspase 3, bcl-x, BDNF 
      increase with lead exposure. Significant treatment effects were not observed for 
      both the cortex and cerebellum.
CI  - (c) 2007 Wiley Periodicals, Inc.
FAU - Chao, Shirley L
AU  - Chao SL
AD  - Department of Natural Sciences, Fayetteville State University, Fayetteville, NC 
      28301, USA. schao@uncfsu.edu
FAU - Moss, Jason M
AU  - Moss JM
FAU - Harry, G Jean
AU  - Harry GJ
LA  - eng
GR  - P20 MD001089/MD/NIMHD NIH HHS/United States
GR  - Z01 ES021164-11/ImNIH/Intramural NIH HHS/United States
GR  - P20 MD001089-01/MD/NIMHD NIH HHS/United States
GR  - N01-ES-25331/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 0 (bcl-X Protein)
RN  - 2P299V784P (Lead)
RN  - EC 3.4.22.- (Caspase 2)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Apoptosis/*drug effects
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Caspase 2/genetics/metabolism
MH  - Caspase 3/genetics/metabolism
MH  - Cerebellum/cytology/*drug effects/*growth & development/metabolism
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Hippocampus/cytology/*drug effects/*growth & development/metabolism
MH  - Lead/blood/*toxicity
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - bcl-2-Associated X Protein/genetics/metabolism
MH  - bcl-X Protein/genetics/metabolism
PMC - PMC2366037
MID - NIHMS44549
EDAT- 2007/10/04 09:00
MHDA- 2008/02/20 09:00
PMCR- 2008/05/03
CRDT- 2007/10/04 09:00
PHST- 2007/10/04 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/10/04 09:00 [entrez]
PHST- 2008/05/03 00:00 [pmc-release]
AID - 10.1002/jbt.20191 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2007;21(5):265-72. doi: 10.1002/jbt.20191.