PMID- 17914131
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20211020
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 26
IP  - 5
DP  - 2007 Oct
TI  - A MUFA-rich diet improves posprandial glucose, lipid and GLP-1 responses in 
      insulin-resistant subjects.
PG  - 434-44
AB  - OBJECTIVE: To study the effects of three weight-maintenance diets with different 
      macronutrient composition on carbohydrate, lipid metabolism, insulin and incretin 
      levels in insulin-resistant subjects. METHODS: A prospective study was performed 
      in eleven (7 W, 4 M) offspring of obese and type 2 diabetes patients. Subjects 
      had a BMI > 25 Kg/m2, waist circumference (men/women) > 102/88, HBA1c < 6.5% and 
      were regarded as insulin-resistant after an OGTT (Matsuda ISIm <4). They were 
      randomly divided into three groups and underwent three dietary periods each of 28 
      days in a crossover design: a) diet high in saturated fat (SAT), b) diet rich in 
      monounsaturated fat (MUFA; Mediterranean diet) and c) diet rich in carbohydrate 
      (CHO). RESULTS: Body weight and resting energy expenditure did not changed during 
      the three dietary periods. Fasting serum glucose concentrations fell during 
      MUFA-rich and CHO-rich diets compared with high-SAT diets (5.02 +/- 0.1, 5.03 +/- 
      0.1, 5.50 +/- 0.2 mmol/L, respectively. Anova < 0.05). The MUFA-rich diet 
      improved insulin sensitivity, as indicated by lower homeostasis model 
      analysis-insulin resistance (HOMA-ir), compared with CHO-rich and high-SAT diets 
      (2.32 +/- 0.3, 2.52 +/- 0.4, 2.72 +/- 0.4, respectively, Anova < 0.01). After a 
      MUFA-rich and high-SAT breakfasts (443 kcal) the postprandial integrated area 
      under curve (AUC) of glucose and insulin were lowered compared with isocaloric 
      CHO-rich breakfast (7.8 +/- 1.3, 5.84 +/- 1.2, 11.9 +/- 2.7 mmol . 180 min/L, 
      Anova < 0.05; and 1004 +/- 147, 1253 +/- 140, 2667 +/- 329 pmol . 180 min/L, 
      Anova <0.01, respectively); while the integrated glucagon-like peptide-1 response 
      increased with MUFA and SAT breakfasts compared with isocaloric CHO-rich meals 
      (4.22 +/- 0.7, 4.34 +/- 1.1, 1.85 +/- 1.1, respectively, Anova < 0.05). Fasting 
      and postprandial HDL cholesterol concentrations rose with MUFA-rich diets, and 
      the AUCs of triacylglycerol fell with the CHO-rich diet. Similarly fasting 
      proinsulin (PI) concentration fell, while stimulated ratio PI/I was not changed 
      by MUFA-rich diet. CONCLUSIONS: Weight maintenance with a MUFA-rich diet improves 
      HOMA-ir and fasting proinsulin levels in insulin-resistant subjects. Ingestion of 
      a virgin olive oil-based breakfast decreased postprandial glucose and insulin 
      concentrations, and increased HDL-C and GLP-1 concentrations as compared with 
      CHO-rich diet.
FAU - Paniagua, Juan A
AU  - Paniagua JA
AD  - Lipids and Atherosclerosis Research Unit, University Hospital Reina Sofia, 
      Cordoba, Spain. japaniaguag@yahoo.es
FAU - de la Sacristana, Angel Gallego
AU  - de la Sacristana AG
FAU - Sanchez, Esther
AU  - Sanchez E
FAU - Romero, Inmaculada
AU  - Romero I
FAU - Vidal-Puig, Antonio
AU  - Vidal-Puig A
FAU - Berral, Francisco J
AU  - Berral FJ
FAU - Escribano, Antonio
AU  - Escribano A
FAU - Moyano, Maria Jose
AU  - Moyano MJ
FAU - Perez-Martinez, Pablo
AU  - Perez-Martinez P
FAU - Lopez-Miranda, Jose
AU  - Lopez-Miranda J
FAU - Perez-Jimenez, Francisco
AU  - Perez-Jimenez F
LA  - eng
GR  - G0400192/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Fats, Unsaturated)
RN  - 0 (Fatty Acids)
RN  - 0 (Incretins)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Analysis of Variance
MH  - Area Under Curve
MH  - Blood Glucose/*metabolism
MH  - Calorimetry, Indirect
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Fats/*administration & dosage
MH  - Dietary Fats, Unsaturated/*administration & dosage
MH  - Fatty Acids/analysis/blood
MH  - Female
MH  - Glucagon-Like Peptide 1/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Incretins/blood
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/metabolism
MH  - Postprandial Period
MH  - Prospective Studies
EDAT- 2007/10/05 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/05 09:00
PHST- 2007/10/05 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/05 09:00 [entrez]
AID - 26/5/434 [pii]
AID - 10.1080/07315724.2007.10719633 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 2007 Oct;26(5):434-44. doi: 10.1080/07315724.2007.10719633.