PMID- 17914192 OWN - NLM STAT- MEDLINE DCOM- 20071109 LR - 20211020 IS - 1073-6085 (Print) IS - 1073-6085 (Linking) VI - 36 IP - 2 DP - 2007 Jun TI - Exploiting dendritic cells for active immunotherapy of cancer and chronic infections. PG - 131-41 AB - Dendritic cells (DCs) are important antigen-presenting cells (APCs) that can prime naive T cells and control adaptive immune responses with respect to magnitude, memory and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infections. This review presents a brief overview of DC biology and of the preparation and use of DC-based vaccines. FAU - O'Neill, David W AU - O'Neill DW AD - Pathology, New York University School of Medicine, Rusk Research Bldg., Room 718, 400 East 34th Street, NewYork, NY 10016, USA. david.o'neill@med.nyu.edu FAU - Bhardwaj, Nina AU - Bhardwaj N LA - eng PT - Journal Article PT - Review PL - Switzerland TA - Mol Biotechnol JT - Molecular biotechnology JID - 9423533 RN - 0 (Cancer Vaccines) RN - 0 (Vaccines) SB - IM MH - Antigen Presentation MH - Cancer Vaccines/immunology/*therapeutic use MH - Chronic Disease MH - Dendritic Cells/*immunology MH - Humans MH - Immunotherapy, Active/*methods MH - Infections/*therapy MH - Neoplasms/*therapy MH - Vaccines/immunology/*therapeutic use RF - 153 EDAT- 2007/10/05 09:00 MHDA- 2007/11/10 09:00 CRDT- 2007/10/05 09:00 PHST- 1999/11/30 00:00 [received] PHST- 1999/11/30 00:00 [revised] PHST- 1999/11/30 00:00 [accepted] PHST- 2007/10/05 09:00 [pubmed] PHST- 2007/11/10 09:00 [medline] PHST- 2007/10/05 09:00 [entrez] AID - MB:36:2:131 [pii] AID - 10.1007/s12033-007-0020-6 [doi] PST - ppublish SO - Mol Biotechnol. 2007 Jun;36(2):131-41. doi: 10.1007/s12033-007-0020-6.