PMID- 17915152
OWN - NLM
STAT- MEDLINE
DCOM- 20071102
LR  - 20190917
IS  - 1579-2242 (Electronic)
IS  - 0300-8932 (Linking)
VI  - 60
IP  - 9
DP  - 2007 Sep
TI  - [Metalloproteases, vascular remodeling and atherothrombotic syndromes].
PG  - 959-67
AB  - Defects in the synthesis and breakdown of the extracellular matrix (ECM) are now 
      seen as key processes in the development of atherosclerosis and its thrombotic 
      complications. Correlations have been observed between circulating levels of ECM 
      biomarkers and the clinical manifestations of and risk factors for 
      atherosclerosis. Several matrix metalloproteinases (MMPs), endopeptidases that 
      can degrade the ECM, such as MMP-9 and MMP-10, play important roles in the 
      pathophysiology of atherothrombosis and contribute to the expansion of abdominal 
      aortic aneurysms. Moreover, they may also be useful biomarkers of atherosclerotic 
      risk and serve as predictors of coronary and cerebrovascular disease recurrence. 
      Although at present the effect of tissue inhibitors of MMPs (TIMPs) on 
      cardiovascular disease prognosis is still uncertain, the ECM could be a promising 
      therapeutic target in atherothrombotic disease, and several MMP inhibitors are 
      currently undergoing clinical trials.
FAU - Rodriguez, Jose A
AU  - Rodriguez JA
AD  - Laboratorio de Aterosclerosis, Area de Ciencias Cardiovasculares, 
      CIMA-Universidad de Navarra, Pamplona, Espana. josean@unav.es
FAU - Orbe, Josune
AU  - Orbe J
FAU - Paramo, Jose A
AU  - Paramo JA
LA  - spa
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Metaloproteasas, remodelado vascular y sindromes aterotromboticos.
PL  - Spain
TA  - Rev Esp Cardiol
JT  - Revista espanola de cardiologia
JID - 0404277
RN  - EC 3.4.- (Metalloproteases)
SB  - IM
CIN - Rev Esp Cardiol. 2008 Mar;61(3):327; author reply 327-8. PMID: 18361910
MH  - Atherosclerosis/*enzymology/*physiopathology
MH  - Blood Vessels/physiopathology
MH  - Extracellular Matrix/physiology
MH  - Humans
MH  - Metalloproteases/*physiology
MH  - Risk Factors
MH  - Syndrome
MH  - Thrombosis/*enzymology/*physiopathology
RF  - 89
EDAT- 2007/10/05 09:00
MHDA- 2007/11/06 09:00
CRDT- 2007/10/05 09:00
PHST- 2007/10/05 09:00 [pubmed]
PHST- 2007/11/06 09:00 [medline]
PHST- 2007/10/05 09:00 [entrez]
AID - 13109649 [pii]
AID - 10.1157/13109649 [doi]
PST - ppublish
SO  - Rev Esp Cardiol. 2007 Sep;60(9):959-67. doi: 10.1157/13109649.