PMID- 17917030
OWN - NLM
STAT- MEDLINE
DCOM- 20080104
LR  - 20211020
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 38
IP  - 1-3
DP  - 2007
TI  - Innovative BMT methods for intractable diseases.
PG  - 251-60
AB  - We have recently established new bone marrow transplantation (BMT) methods for 
      the treatment of intractable diseases. The methods include the perfusion method 
      (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for 
      the direct injection of collected whole bone marrow cells into the bone marrow 
      cavity. The PM, in comparison with the conventional aspiration method, can 
      minimize the contamination of bone marrow cells (BMCs) with T cells from the 
      peripheral blood. Therefore, without removing T cells, no graft-versus-host 
      disease (GvHD) develops in the case of the PM. Since BMCs collected by the PM 
      contain not only hemopoietic stem cells (HSCs) but also mesenchymal stem cells 
      (MSCs), the injection of both cells directly into the bone marrow cavity 
      (IBM-BMT) facilitates the engraftment of donor hemopoietic cells. In organ 
      allografts with IBM-BMT, no graft failure occurs even if the radiation dose is 
      reduced. In addition, IBM-BMT is applicable to regeneration therapy and various 
      age-associated diseases such as osteoporosis, since it can efficiently recruit 
      donor-derived normal MSCs. Finally, we show that IBM-BMT in conjunction with 
      donor lymphocyte infusion (DLI) can prevent GvHD but suppress tumor growth. We 
      believe that this strategy heralds a revolution in the field of transplantation 
      (BMT and organ allografts) and regeneration therapy.
FAU - Ikehara, Susumu
AU  - Ikehara S
AD  - First Department of Pathology, Transplantation Center, Regeneration Research 
      Center for Intractable Diseases, Center for Cancer Therapy, Kansai Medical 
      University, Moriguchi City, Osaka 570-8506, Japan. ikehara@takii.kmu.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/surgery
MH  - Bone Marrow Transplantation/*methods
MH  - Chronic Disease
MH  - Graft vs Host Disease/*prevention & control
MH  - Major Histocompatibility Complex/immunology
MH  - Mice
MH  - Mice, SCID
MH  - Neoplasms/surgery
MH  - Osteoporosis/surgery
EDAT- 2007/10/06 09:00
MHDA- 2008/01/05 09:00
CRDT- 2007/10/06 09:00
PHST- 1999/11/30 00:00 [received]
PHST- 1999/11/30 00:00 [revised]
PHST- 1999/11/30 00:00 [accepted]
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/01/05 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - IR:38:1-3:251 [pii]
AID - 10.1007/s12026-007-0004-4 [doi]
PST - ppublish
SO  - Immunol Res. 2007;38(1-3):251-60. doi: 10.1007/s12026-007-0004-4.