PMID- 17917677
OWN - NLM
STAT- MEDLINE
DCOM- 20080208
LR  - 20221207
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 8
DP  - 2007 Dec
TI  - Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on 
      chromosome 3: the NHLBI family heart study follow-up examination.
PG  - 684-90
AB  - Atherogenesis is a chronic inflammatory process. Critical in the inflammation 
      process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions 
      that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in 
      a sample of whites and blacks. Phenotype and genetic marker data were available 
      for 2501 white and 513 black participants in the National Heart Lung Blood 
      Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 
      0.37 in whites and 0.47 in blacks after adjusting for the effects of sex, age, 
      age-sex interaction, smoking status, lifetime smoking exposure (pack-years) and 
      field center. Significant linkage was observed for MCP-1 in a combined black and 
      white sample on chromosome 3 (logarithm of the odds ratio (LOD)=3.5 at 78 cM, 
      P=0.0001) and suggestive linkage was observed in whites on chromosome 5 (LOD=1.8 
      at 128 cM, P=0.002). Located under the linkage peak on chromosome 3 is the 
      chemokine receptor gene cluster, including CCR2, the receptor for MCP-1. This 
      study provides preliminary evidence linking genetic variation in a receptor to 
      circulating levels of its ligand, as previously demonstrated for the low-density 
      lipoprotein receptor. Further characterization of these chromosomal regions is 
      needed to identify the functional mutations associated with circulating levels of 
      MCP-1.
FAU - Bielinski, S J
AU  - Bielinski SJ
AD  - Division of Epidemiology and Community Health, University of Minnesota, 
      Minneapolis, MN 55454, USA. bielinski@epi.umm.edu
FAU - Pankow, J S
AU  - Pankow JS
FAU - Miller, M B
AU  - Miller MB
FAU - Hopkins, P N
AU  - Hopkins PN
FAU - Eckfeldt, J H
AU  - Eckfeldt JH
FAU - Hixson, J
AU  - Hixson J
FAU - Liu, Y
AU  - Liu Y
FAU - Register, T
AU  - Register T
FAU - Myers, R H
AU  - Myers RH
FAU - Arnett, D K
AU  - Arnett DK
LA  - eng
GR  - T32 HL007972/HL/NHLBI NIH HHS/United States
GR  - U01 HL56563/HL/NHLBI NIH HHS/United States
GR  - U01 HL56564/HL/NHLBI NIH HHS/United States
GR  - U01 HL56565/HL/NHLBI NIH HHS/United States
GR  - U01 HL56566/HL/NHLBI NIH HHS/United States
GR  - U01 HL56567/HL/NHLBI NIH HHS/United States
GR  - U01 HL56568/HL/NHLBI NIH HHS/United States
GR  - U01 HL56569/HL/NHLBI NIH HHS/United States
GR  - U01 HL67893/HL/NHLBI NIH HHS/United States
GR  - U01 HL67894/HL/NHLBI NIH HHS/United States
GR  - U01 HL67895/HL/NHLBI NIH HHS/United States
GR  - U01 HL67896/HL/NHLBI NIH HHS/United States
GR  - U01 HL67897/HL/NHLBI NIH HHS/United States
GR  - U01 HL67898/HL/NHLBI NIH HHS/United States
GR  - U01 HL67899/HL/NHLBI NIH HHS/United States
GR  - U01 HL67900/HL/NHLBI NIH HHS/United States
GR  - U01 HL67901/HL/NHLBI NIH HHS/United States
GR  - U01 HL67902/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071004
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atherosclerosis/*genetics
MH  - Black People/genetics
MH  - Chemokine CCL2/*blood
MH  - Chromosomes, Human, Pair 3/*genetics
MH  - Female
MH  - *Genetic Linkage
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multigene Family
MH  - National Heart, Lung, and Blood Institute (U.S.)
MH  - Receptors, Chemokine/*genetics
MH  - United States/ethnology
MH  - White People/genetics
EDAT- 2007/10/06 09:00
MHDA- 2008/02/09 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/02/09 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 6364434 [pii]
AID - 10.1038/sj.gene.6364434 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Dec;8(8):684-90. doi: 10.1038/sj.gene.6364434. Epub 2007 Oct 4.