PMID- 17917681
OWN - NLM
STAT- MEDLINE
DCOM- 20080430
LR  - 20171116
IS  - 1350-9047 (Print)
IS  - 1350-9047 (Linking)
VI  - 15
IP  - 3
DP  - 2008 Mar
TI  - The shadow of death on the MET tyrosine kinase receptor.
PG  - 427-34
AB  - The MET tyrosine kinase receptor is a high-affinity receptor for hepatocyte 
      growth factor/scatter factor (HGF/SF). HGF/SF-MET system is necessary for 
      embryonic development, and aberrant MET signalling favours tumorigenesis and 
      metastasis. MET is a prototype of tyrosine kinase receptor, which is able to 
      counteract apoptosis through the initiation of a survival signal involving 
      notably the PI3K-Akt pathway. Paradoxically, the MET receptor is also able to 
      promote apoptosis when activated by HGF/SF or independently of ligand 
      stimulation. The molecular mechanisms underlying this uncommon response have been 
      recently investigated and revealed dual antiapoptotic or proapoptotic property of 
      MET according to the cell type or stress conditions. Although the involvement of 
      MET in the regulation of integrated biological responses mostly took into account 
      its efficient antiapoptotic function, its proapoptotic responses could also be 
      important for regulation of the survival/apoptosis balance and play a role during 
      the development or tumour progression.
FAU - Tulasne, D
AU  - Tulasne D
AD  - CNRS UMR 8161, Institut de Biologie de Lille-Institut Pasteur de Lille-Universite 
      de Lille 1-Universite de Lille 2, IFR142, B.P.447, 59021 Lille Cedex, France. 
      david.tulasne@ibl.fr
FAU - Foveau, B
AU  - Foveau B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071005
PL  - England
TA  - Cell Death Differ
JT  - Cell death and differentiation
JID - 9437445
RN  - 0 (fas Receptor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Caspases/metabolism
MH  - Cell Survival
MH  - Humans
MH  - Neoplasms/metabolism
MH  - Proto-Oncogene Proteins c-met/*metabolism
MH  - Signal Transduction
MH  - fas Receptor/metabolism
RF  - 100
EDAT- 2007/10/06 09:00
MHDA- 2008/05/01 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/05/01 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 4402229 [pii]
AID - 10.1038/sj.cdd.4402229 [doi]
PST - ppublish
SO  - Cell Death Differ. 2008 Mar;15(3):427-34. doi: 10.1038/sj.cdd.4402229. Epub 2007 
      Oct 5.