PMID- 17917696
OWN - NLM
STAT- MEDLINE
DCOM- 20081009
LR  - 20131121
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 35
IP  - 2
DP  - 2008 Aug
TI  - Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and 
      PGE2 after a half-ironman competition.
PG  - 425-31
AB  - OBJECTIVE: The effect of creatine supplementation upon plasma levels of 
      pro-inflammatory cytokines: Interleukin (IL) 1 beta and IL-6, Tumor Necrosis 
      Factor alpha (TNFalpha), and Interferon alpha (INF alpha) and Prostaglandin E(2) 
      (PGE(2)) after a half-ironman competition were investigated. METHODS: Eleven 
      triathletes, each with at least three years experience of participation in this 
      sport were randomly divided between the control and experimental groups. During 5 
      days prior to competition, the control group (n = 6) was supplemented with 
      carbohydrate (20 g x d(-1)) whereas the experimental group (n = 5) received 
      creatine (20 g x d(-1)) in a double-blind trial. Blood samples were collected 48 
      h before and 24 and 48 h after competition and were used for the measurement of 
      cytokines and PGE(2). RESULTS: Forty-eight hours prior to competition there was 
      no difference between groups in the plasma concentrations (pg x ml(-1), mean +/- 
      SEM) of IL-6 (7.08 +/- 0.63), TNFalpha (76.50 +/- 5.60), INF alpha (18.32 +/- 
      1.20), IL-1 beta (23.42 +/- 5.52), and PGE(2) (39.71 +/- 3.8). Twenty-four and 48 
      h after competition plasma levels of TNFalpha, INF alpha, IL-1 beta and PGE(2) 
      were significantly increased (P < 0.05) in both groups. However, the increases in 
      these were markedly reduced following creatine supplementation. An increase in 
      plasma IL-6 was observed only after 24 h and, in this case, there was no 
      difference between the two groups. CONCLUSION: Creatine supplementation before a 
      long distance triathlon competition may reduce the inflammatory response induced 
      by this form of strenuous of exercise.
FAU - Bassit, R A
AU  - Bassit RA
AD  - Department of Cellular Biology, Institute of Biomedical Sciences, University of 
      Sao Paulo, Sao Paulo, Sp, Brazil. tubaraousp@sti.com.br
FAU - Curi, R
AU  - Curi R
FAU - Costa Rosa, L F B P
AU  - Costa Rosa LF
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20071004
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0 (Cytokines)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adult
MH  - Creatine/*administration & dosage
MH  - Cytokines/*blood
MH  - *Dietary Supplements
MH  - Dinoprostone/*blood
MH  - Humans
MH  - Inflammation/*prevention & control
MH  - Middle Aged
MH  - Physical Endurance/drug effects/*physiology
MH  - Running
MH  - Swimming
EDAT- 2007/10/06 09:00
MHDA- 2008/10/10 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/05/03 00:00 [received]
PHST- 2007/07/05 00:00 [accepted]
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/10/10 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 10.1007/s00726-007-0582-4 [doi]
PST - ppublish
SO  - Amino Acids. 2008 Aug;35(2):425-31. doi: 10.1007/s00726-007-0582-4. Epub 2007 Oct 
      4.