PMID- 17917837
OWN - NLM
STAT- MEDLINE
DCOM- 20080811
LR  - 20080514
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 128
IP  - 3
DP  - 2008 Mar
TI  - Clinicopathologic significance and prognostic role of cyclin E and cyclin A 
      expression in laryngeal epithelial lesions.
PG  - 329-34
AB  - CONCLUSIONS: The determination of cyclin A expression might be helpful in the 
      identification of laryngeal squamous cell cancer (LSCC) patients with increased 
      risk of metastases. The results suggest that cyclin A may be a more informative 
      marker for cell proliferation than Ki-67. Abnormalities of cyclin E and cyclin A 
      may play an important role in LSCC development and progression; however, the 
      expression of cyclin E does not seem to have prognostic significance. OBJECTIVE: 
      The aim of the study was to elucidate a possible association between cyclin E and 
      cyclin A expression and clinicopathologic factors and their potential role as 
      prognostic markers for patients with laryngeal epithelial lesions. MATERIALS AND 
      METHODS: Expression of cyclins E and A, and Ki-67 was examined 
      immunohistochemically in a formalin-fixed, paraffin-embedded series of 46 LSCC; 
      23 epithelial dysplasias (ED); and 21 normal mucosae (NM). RESULTS: The mean 
      labeling indices (LIs) for cyclin E in LSCC, ED, and NM were 10.6%, 4.9%, and 0%, 
      and for cyclin A 27.2%, 17.5%, and 7%, respectively. In LSCC, a statistically 
      significant correlation was found between enhanced cyclin A expression and a 
      higher incidence of locoregional lymph node metastasis (p0.01). The enhanced 
      expression of cyclin A was linked with cell proliferation in LSCC, ED, and NM. No 
      association was observed between cyclin E and A and other clinicopathologic 
      parameters or applied treatments. The prognostic significance of cyclin E, cyclin 
      A, and Ki-67 in determining overall survival time showed no statistically 
      significant differences.
FAU - Fraczek, Marcin
AU  - Fraczek M
AD  - Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland. 
      raucedo@wp.pl
FAU - Wozniak, Zbigniew
AU  - Wozniak Z
FAU - Ramsey, David
AU  - Ramsey D
FAU - Zatonski, Tomasz
AU  - Zatonski T
FAU - Krecicki, Tomasz
AU  - Krecicki T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (Cyclin A)
RN  - 0 (Cyclin E)
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Division/genetics
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Cyclin A/*genetics
MH  - Cyclin E/*genetics
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Ki-67 Antigen/genetics
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Lymphatic Metastasis/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Respiratory Mucosa/*pathology
EDAT- 2007/10/06 09:00
MHDA- 2008/08/12 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/08/12 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 782850941 [pii]
AID - 10.1080/00016480701487742 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2008 Mar;128(3):329-34. doi: 10.1080/00016480701487742.