PMID- 17917931
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20131121
IS  - 0020-7454 (Print)
IS  - 0020-7454 (Linking)
VI  - 117
IP  - 11
DP  - 2007 Nov
TI  - Early preweaning methamphetamine and postweaning rearing conditions interfere 
      with the development of peripheral stress parameters and neural growth factors in 
      gerbils.
PG  - 1621-38
AB  - Adrenal steroid hormones and neuronal growth factors are two interacting systemic 
      factors that mediate the environment's influence on the brain's structure and 
      function. In order to further elucidate their role and relationship in the 
      effects of early stressful experience and isolated rearing (IR), this study 
      measured blood corticosterone titres and relative adrenal weights and assessed 
      nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) 
      concentrations in brain regions of both hemispheres of young adult Mongolian 
      gerbils injected on postnatal day 14 with a single high dose of methamphetamine 
      (MA) or saline and raised after weaning either in an enriched or an impoverished 
      environment. Irrespective of MA challenge, IR decreased corticosterone titres to 
      about half, but increased relative adrenal weights. BDNF concentrations were 
      decreased by IR in saline-injected animals in the left prefrontal and parietal 
      cortices and right entorhinal and hippocampal cortices, and in the subcortical 
      regions of both hemispheres. NGF concentrations were unaltered by IR in 
      saline-injected animals, but increased in MA challenged animals in the 
      entorhinal/hippocampal cortices and subcortical areas of both hemispheres. MA 
      application induced shifts of the lateral asymmetry in NGF contents in prefrontal 
      and entorhinal cortices. The results suggest that an early pharmacological 
      traumatization can set a switch for further brain development, and that growth 
      factor concentrations might possibly be influenced by peripheral stress hormones.
FAU - Lehmann, Konrad
AU  - Lehmann K
AD  - Department of Neuroanatomy, Faculty of Biology, Bielefeld, Germany. 
      Konrad.Lehmann@uni-jena.de
FAU - Rodriguez, Enrique Garea
AU  - Rodriguez EG
FAU - Kratz, Oliver
AU  - Kratz O
FAU - Moll, Gunther H
AU  - Moll GH
FAU - Dawirs, Ralph R
AU  - Dawirs RR
FAU - Teuchert-Noodt, Gertraud
AU  - Teuchert-Noodt G
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Nerve Growth Factors)
RN  - 44RAL3456C (Methamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Glands/pathology
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System Stimulants/*administration & dosage/pharmacology
MH  - Corticosterone/blood
MH  - Dominance, Cerebral
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - *Environment
MH  - Gerbillinae
MH  - Male
MH  - Methamphetamine/*administration & dosage/pharmacology
MH  - Nerve Growth Factors/*metabolism
MH  - Organ Size
MH  - Social Isolation
MH  - Stress, Physiological/etiology/*pathology/*physiopathology
MH  - *Weaning
EDAT- 2007/10/06 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 782799771 [pii]
AID - 10.1080/00207450600934937 [doi]
PST - ppublish
SO  - Int J Neurosci. 2007 Nov;117(11):1621-38. doi: 10.1080/00207450600934937.