PMID- 17918236
OWN - NLM
STAT- MEDLINE
DCOM- 20080205
LR  - 20211027
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 144B
IP  - 8
DP  - 2007 Dec 5
TI  - Association study of the brain-derived neurotropic factor (BDNF) gene in 
      attention deficit hyperactivity disorder.
PG  - 976-81
AB  - Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental 
      childhood psychiatric disorder. Brain-derived neurotropic factor (BDNF) has been 
      suggested to play a role in the pathogenesis of ADHD and two family-based 
      association studies demonstrated an association of BDNF polymorphisms with ADHD. 
      The aim of the current study was to investigate the BDNF gene for association 
      with ADHD in a large sample of families from Toronto. The transmission of three 
      polymorphisms of the BDNF gene (rs6265, rs11030104, and rs2049046) was examined 
      in 266 nuclear families ascertained through a proband with ADHD (315 affected 
      children) using the transmission/disequilibrium test (TDT). In addition, we 
      conducted quantitative analysis to assess the relationship between these marker 
      alleles and the symptom dimensions of ADHD (inattention and 
      hyperactivity/impulsivity) and cognitive measures of working memory. None of the 
      individual marker alleles showed significant evidence of association with ADHD, 
      dimensional symptom scores, or working memory ability in our sample of ADHD 
      families. There was no significant evidence for biased transmission of individual 
      haplotypes with frequency >10% (global chi2 for these three haplotypes: chi2 = 
      6.349, df = 3, P = 0.096). One uncommon haplotype (A-G-G; frequency 2.2%) showed 
      a significant association with ADHD in the categorical (chi2 = 5.293, df = 1, P = 
      0.021) and quantitative analyses (parents' rated inattention: Z = -2.504, P = 
      0.012; and hyperactivity/impulsivity: Z = -2.651, P = 0.008). These results 
      should be interpreted cautiously, however, because of the low haplotype 
      frequency. In light of the evidence for an involvement of BDNF in ADHD, further 
      analysis of the BDNF gene in ADHD is warranted.
CI  - 2007 Wiley-Liss, Inc.
FAU - Lee, Jonghun
AU  - Lee J
AD  - Cell and Molecular Biology Division, Toronto Western Research Institute, 
      University Health Network, Toronto, Ontario, Canada.
FAU - Laurin, Nancy
AU  - Laurin N
FAU - Crosbie, Jennifer
AU  - Crosbie J
FAU - Ickowicz, Abel
AU  - Ickowicz A
FAU - Pathare, Tejaswee
AU  - Pathare T
FAU - Malone, Molly
AU  - Malone M
FAU - Tannock, Rosemary
AU  - Tannock R
FAU - Kennedy, James L
AU  - Kennedy JL
FAU - Schachar, Russell
AU  - Schachar R
FAU - Barr, Cathy L
AU  - Barr CL
LA  - eng
GR  - 14336-1/CAPMC/CIHR/Canada
GR  - 14336-2/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Attention Deficit Disorder with Hyperactivity/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Siblings
EDAT- 2007/10/06 09:00
MHDA- 2008/02/06 09:00
CRDT- 2007/10/06 09:00
PHST- 2007/10/06 09:00 [pubmed]
PHST- 2008/02/06 09:00 [medline]
PHST- 2007/10/06 09:00 [entrez]
AID - 10.1002/ajmg.b.30437 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 5;144B(8):976-81. doi: 
      10.1002/ajmg.b.30437.