PMID- 1791875
OWN - NLM
STAT- MEDLINE
DCOM- 19920330
LR  - 20051117
IS  - 0300-2977 (Print)
IS  - 0300-2977 (Linking)
VI  - 39
IP  - 3-4
DP  - 1991 Oct
TI  - Light chain deposition disease without detectable light chains in serum or urine. 
      Report of a case and review of the literature.
PG  - 142-7
AB  - A patient presenting with a nephrotic syndrome and chronic renal failure caused 
      by light chain deposition disease (LCDD) without detectable light chains in serum 
      and urine is presented. Only a few patients with LCDD but without detectable 
      light chains in serum and urine have hitherto been reported. The diagnosis was 
      made by light-microscopic and immunofluorescent examination of a percutaneous 
      renal biopsy. The histological differential diagnosis of LCDD includes diabetic 
      glomerulosclerosis, renal amyloidosis and membranoproliferative 
      glomerulonephritis. For the histological diagnosis of LCDD, immunofluorescence 
      using anti-kappa and anti-lambda antisera is essential. Although renal 
      involvement is a constant feature in LCDD, other sites of deposition of light 
      chains have been reported. The absence of detectable light chains in serum or 
      urine is discussed.
FAU - van Ingen, G
AU  - van Ingen G
AD  - Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
FAU - van Bronswijk, H
AU  - van Bronswijk H
FAU - Meijer, C J
AU  - Meijer CJ
FAU - Stel, H V
AU  - Stel HV
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Neth J Med
JT  - The Netherlands journal of medicine
JID - 0356133
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Biopsy
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - Hypergammaglobulinemia/*blood/complications/urine
MH  - Immunoglobulin Light Chains/*analysis/blood/urine
MH  - Kidney/chemistry/pathology/ultrastructure
MH  - Kidney Failure, Chronic/*etiology/pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Nephrotic Syndrome/*etiology/pathology
RF  - 13
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
PST - ppublish
SO  - Neth J Med. 1991 Oct;39(3-4):142-7.