PMID- 17919204
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20071008
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 46 Suppl 1
DP  - 2007 Oct
TI  - Mycosis fungoides and Sezary syndrome against a human immunodeficiency 
      virus-positive background: case report.
PG  - 32-5
AB  - BACKGROUND: Mycosis fungoides (MF) and Sezary syndrome (SS) are forms of primary 
      cutaneous T-cell lymphoma. They are relatively rare diseases, infrequent in 
      Europe, Asia, and Africa. In Rwanda, they remain very rare. Their 
      etiopathogenesis has long been obscure and poorly understood. Recent studies, 
      however, have confirmed that they are of viral origin, specifically human T-cell 
      lymphotropic virus type I (HTLV-I) and human immunodeficiency virus (HIV). Their 
      incidence is low: about three new cases per year per million inhabitants. 
      Individuals affected are usually aged between 40 and 60 years and of male gender. 
      The incidence of SS is less than one new case per year per million inhabitants. 
      METHODS: A new case of MF/SS syndrome against a HIV-positive background is 
      described and a literature review is performed. RESULTS: Clinically, MF is 
      characterized at onset by pruriginous, disseminated, erythematous, scaly plaques, 
      localized on the skin, which gradually become infiltrative. In advanced stages, 
      the nodular lesions can become ulcerated and Sezary cells are detected in the 
      peripheral blood. Our male Rwandan MF/SS/HIV-positive patient presented with 
      pruriginous, erythematous, scaly lesions, which had developed over 4 years and 
      were now infiltrative, together with nodular lesions of various sizes, localized 
      on the face, scalp, and palmar and plantar regions. All of these clinical signs, 
      the anatomopathologic examination, retroviral serology, and testing of peripheral 
      blood confirmed the diagnosis of MF/SS against a background of immunodepression. 
      CONCLUSIONS: MF and SS are relatively rare cutaneous lymphomas, but have been 
      diagnosed in Rwanda against a clinical picture of immunodepression. Their 
      etiology seems to be viral in origin. MF and SS are difficult diseases to 
      diagnose, with confirmation only at advanced stages. No tests exist to aid and 
      confirm the diagnosis in the initial stages of the diseases. Further studies are 
      urgently needed on these diseases.
FAU - Gahongayire, Francoise
AU  - Gahongayire F
AD  - King Faisal Hospital, Kigali, Rwanda. fgahon@yahoo.fr
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - *HIV/isolation & purification
MH  - HIV Infections/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mycosis Fungoides/*etiology/pathology
MH  - Rwanda
MH  - Sezary Syndrome/*etiology/pathology
MH  - Skin Neoplasms/pathology
EDAT- 2007/10/09 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/09 09:00
PHST- 2007/10/09 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/09 09:00 [entrez]
AID - IJD3461 [pii]
AID - 10.1111/j.1365-4632.2007.03461.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2007 Oct;46 Suppl 1:32-5. doi: 10.1111/j.1365-4632.2007.03461.x.