PMID- 17919266
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 70
IP  - 5
DP  - 2007 Nov
TI  - Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients 
      with type 1 diabetes and their relatives.
PG  - 369-75
AB  - The objective of this study was to explore the relationship between islet 
      autoantibodies of glutamic acid decarboxylase (GADA), islet antigen-2A (IA-2A), 
      insulin autoantibody (IAA), and human leukocyte antigen (HLA)-DQ genotypes in 
      type 1 diabetes (T1D) patients and their first-degree relatives (FDRs). 
      Cross-sectional and case-control study. Four hundred and ninety-five T1D 
      patients, 419 FDRs, and 376 control subjects in Han Chinese populations were 
      recruited and tested for GADA and IA-2A, while 71 cases, all FDRs and 300 
      controls were tested for IAA. The 338 T1D patients (including 187 
      antibody-positive and 151 antibody-negative patients), 173 FDRs and 278 controls 
      were genotyped for HLA-DQ with polymerase chain reaction sequencing-based method. 
      Compared with the control, the frequency of DQA1*03-DQB1*0303, DQA1*05-DQB1*0201, 
      and DQA1*03-DQB1*0401 haplotypes was higher (P < 0.05-0.01) but 
      DQA1*0102-DQB1*0602 haplotype was lower (P < 0.01) in T1D patients. DQA1*03 
      allele was less in the FDRs than in their probands (P < 0.05). GADA was more 
      prevalent in T1D patients carrying DQA1*05-DQB1*0201 or DQA1*03-DQB1*0401 
      haplotype (55.8% vs 41.0%, 65.5% vs 40.3%, P < 0.05-0.01), whereas IA-2A 
      presented more in the patients carrying DQA1*03-DQB1*0303 haplotype (27.0% vs 
      7.9%, P < 0.05-0.01), both GADA and IA-2A showed frequently in the patients with 
      DQA1*03-DQB1*0303/DQA1*05-DQB1*0201 haplotypes (34.5% vs 9.7%, P < 0.01). GADA 
      positivity was lower in the patients with DQA1*0102-DQB1*0602 haplotype (16.7% vs 
      45.9%, P < 0.05). The frequency of IAA was not different between patients with 
      and without susceptible DQ haplotypes (P > 0.05). GADA, IA-2A or IAA presented 
      frequently in FDRs with DQA1*03-DQB1*0303 haplotype. The findings in the study 
      indicate that some of specific HLA-DQA1/-DQB1 genotypes and haplotypes not only 
      confer susceptibility to T1D but also are associated with the presence of the 
      islet autoantibodies in the Han Chinese population.
FAU - Wang, J-P
AU  - Wang JP
AD  - Department of Endocrinology, Diabetes Center, Institute of Metabolism and 
      Endocrinology, Second Xiangya Hospital, Central South University, Changsha, 
      Hunan, China.
FAU - Zhou, Z-G
AU  - Zhou ZG
FAU - Lin, J
AU  - Lin J
FAU - Huang, G
AU  - Huang G
FAU - Zhang, C
AU  - Zhang C
FAU - Yang, L
AU  - Yang L
FAU - Yuan, Y
AU  - Yuan Y
FAU - Zhou, H-F
AU  - Zhou HF
FAU - Zhou, M
AU  - Zhou M
FAU - Hou, C
AU  - Hou C
FAU - Zhou, W-D
AU  - Zhou WD
FAU - Peng, H
AU  - Peng H
FAU - Hagopian, W A
AU  - Hagopian WA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Insulin Antibodies)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (islet cell antibody)
RN  - EC 3.1.3.48 (PTPRN protein, human)
RN  - EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 8)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Autoantibodies/genetics/*immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - Family
MH  - Female
MH  - Gene Frequency/immunology
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Glutamate Decarboxylase/genetics/immunology
MH  - HLA-DQ Antigens/*genetics/immunology
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Insulin Antibodies/genetics/immunology
MH  - Male
MH  - Membrane Glycoproteins/*genetics/immunology
MH  - Middle Aged
MH  - Receptor-Like Protein Tyrosine Phosphatases, Class 8/genetics/immunology
EDAT- 2007/10/09 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/09 09:00
PHST- 2007/10/09 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/09 09:00 [entrez]
AID - TAN916 [pii]
AID - 10.1111/j.1399-0039.2007.00916.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Nov;70(5):369-75. doi: 10.1111/j.1399-0039.2007.00916.x.