PMID- 17922434
OWN - NLM
STAT- MEDLINE
DCOM- 20090313
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 24
IP  - 5
DP  - 2007 Oct
TI  - [Association of -63A/C polymorphism of glutathione S-transferase M3 gene with 
      essential hypertension in Chinese population].
PG  - 582-5
AB  - OBJECTIVE: To investigate the distribution of -63A/C polymorphism of human 
      glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the 
      association of -63A/C polymorphism with essential hypertension (EH). METHODS: 
      -63A/C polymorphism of GSTM3 gene was examined by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) in 234 patients with 
      EH and 328 healthy controls. The genotypes were confirmed partially by DNA 
      sequencing. RESULTS: The distribution of GSTM3 -63A/C was in Hardy-Weinberg 
      equilibrium. The CC genotype frequency in EH group (6%) was significantly higher 
      than that in control group(1.8%) (P < 0.05). After adjustment for age, body mass 
      index, and other risk factors, the CC genotype was independently associated with 
      hypertension (OR=3.447, 95%CI: 1.19-7.63; P=0.04). CONCLUSION: The GSTM3 -63A/C 
      polymorphism was associated with EH in Chinese Han population, the C allele might 
      be a risk factor for EH in Chinese Han nationality.
FAU - Liu, Jian
AU  - Liu J
AD  - Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 
      110001 PR China.
FAU - Li, Miao
AU  - Li M
FAU - Qi, Man-long
AU  - Qi ML
FAU - Liu, Xiao-liang
AU  - Liu XL
FAU - Li, Ying-hui
AU  - Li YH
FAU - Fu, Ling-yu
AU  - Fu LY
FAU - Zhao, Yan-yan
AU  - Zhao YY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Isoenzymes)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione transferase M3-3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/*genetics
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Hypertension/*genetics/pathology
MH  - Isoenzymes/genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Regression Analysis
EDAT- 2007/10/09 09:00
MHDA- 2009/03/14 09:00
CRDT- 2007/10/09 09:00
PHST- 2007/10/09 09:00 [pubmed]
PHST- 2009/03/14 09:00 [medline]
PHST- 2007/10/09 09:00 [entrez]
AID - 940624135 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):582-5.