PMID- 17922439
OWN - NLM
STAT- MEDLINE
DCOM- 20090313
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 24
IP  - 5
DP  - 2007 Oct
TI  - [Relationship between genetic polymorphism of MCP-1 and acute pancreatitis in Han 
      population of Suzhou in China].
PG  - 598-600
AB  - OBJECTIVE: To study the relationship between monocyte chemoattractant protein-1 
      gene (MCP-1) -2518A/G polymorphism and acute pancreatitis (AP) in the Han 
      population of Suzhou, China. METHODS: The polymorphisms were detected with 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). 
      The genotypes and allele frequencies of MCP-1 -2518A/G were calculated and 
      analyzed in 101 AP patients including 78 mild AP (MAP) patients and 23 severe AP 
      (SAP) patients, and 120 healthy individuals as control group. RESULTS: The 
      frequency of MCP-1 -2518 AA genotype in control group was significantly higher 
      than that in SAP and MAP groups (P < 0.01). People with AG and GG genotypes had 
      5.896 times risk of developing MAP (P < 0.01, OR=5.896) compared with people with 
      AA genotype. Subjects carrying G allele were at a 7-fold elevated risk for SAP (P 
      < 0.05, OR=7.011) contrasted with subjects carrying AA genotype. However, no 
      difference in AA genotypic distribution was noted between MAP and SAP groups (chi 
      square=0.006, P=0.997). The frequency of G allele in healthy controls was 
      obviously lower than that in MAP (P < 0.01, OR=0.318) and SAP groups (P < 0.01, 
      OR=0.309). No difference of G allele frequency was found between SAP group and 
      MAP group (P=0.623, OR=1.211). CONCLUSION: The MCP-1 -2518 AA genotype of the 
      population in Suzhou may be a protective genotype of AP. People with higher 
      frequency of G allele is more likely to suffer from AP. Nonetheless, the genotype 
      of AA and the frequency of G allele couldn't predict the risk of SAP.
FAU - Nie, Jin-shan
AU  - Nie JS
AD  - Department of Gastroenterology, the First Affiliated Hospital, Soochow 
      University, Suzhou, Jiangsu, 215006 PR China.
FAU - Chen, Wei-chang
AU  - Chen WC
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - China/ethnology
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*genetics
MH  - *Polymorphism, Single Nucleotide
EDAT- 2007/10/09 09:00
MHDA- 2009/03/14 09:00
CRDT- 2007/10/09 09:00
PHST- 2007/10/09 09:00 [pubmed]
PHST- 2009/03/14 09:00 [medline]
PHST- 2007/10/09 09:00 [entrez]
AID - 940624140 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Oct;24(5):598-600.