PMID- 17923357
OWN - NLM
STAT- MEDLINE
DCOM- 20071128
LR  - 20071009
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 13
IP  - 8
DP  - 2007 Oct
TI  - Impact of atrial fibrillation in heart failure with normal ejection fraction: a 
      clinical and echocardiographic study.
PG  - 649-55
AB  - BACKGROUND: The clinical significance of atrial fibrillation (AF) in heart 
      failure with normal ejection fraction (HFNEF) remains undetermined. METHODS AND 
      RESULTS: We compared the clinical and echocardiographic characteristics among 238 
      patients hospitalized for HF. Using the cutoff of left ventricular EF of 50%, 
      there were 146 patients with HFNEF (AF = 42) and 92 with systolic HF (AF = 30). 
      When compared among HFNEF, the New York Heart Association (NYHA) class (2.61 +/- 
      0.51 versus 2.21 +/- 0.46; P < .05), 6-minute walk distance (279.7 +/- 66.0 
      versus 338.0 +/- 86.1 m; P < .01), quality of life score (26.1 +/- 14.3 versus 
      19.5 +/- 10.3; P < .05), and previous HF hospitalization were significantly worse 
      in the AF group. These variables were significantly better in HFNEF than systolic 
      HF with sinus rhythm, but the differences were not detected among those with AF. 
      Patients with HFNEF and AF were associated with more severe diastolic dysfunction 
      when compared to sinus rhythm. With a median follow-up of 10.5 months, the 
      proportion of HFNEF patients in AF with recurrent HF hospitalization or death was 
      significantly higher than those in sinus rhythm (28.6% versus 10.6%; P < .01). 
      Both AF and restrictive diastolic dysfunction were independent predictors of HF 
      hospitalization or death in HFNEF. CONCLUSION: Patients with HFNEF and AF were 
      associated with more severe diastolic dysfunction and worse clinical outcomes 
      than those in sinus rhythm.
FAU - Fung, Jeffrey W H
AU  - Fung JW
AD  - Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales 
      Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.
FAU - Sanderson, John E
AU  - Sanderson JE
FAU - Yip, Gabriel W K
AU  - Yip GW
FAU - Zhang, Qing
AU  - Zhang Q
FAU - Yu, Cheuk M
AU  - Yu CM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/*complications/*epidemiology/physiopathology
MH  - *Echocardiography/trends
MH  - Female
MH  - Heart Failure/*complications/*epidemiology/physiopathology
MH  - Hospitalization/trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/*physiology
EDAT- 2007/10/10 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/10/10 09:00
PHST- 2006/11/18 00:00 [received]
PHST- 2007/04/25 00:00 [revised]
PHST- 2007/04/26 00:00 [accepted]
PHST- 2007/10/10 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/10/10 09:00 [entrez]
AID - S1071-9164(07)00158-3 [pii]
AID - 10.1016/j.cardfail.2007.04.014 [doi]
PST - ppublish
SO  - J Card Fail. 2007 Oct;13(8):649-55. doi: 10.1016/j.cardfail.2007.04.014.