PMID- 17923424
OWN - NLM
STAT- MEDLINE
DCOM- 20080715
LR  - 20131121
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 89
IP  - 4
DP  - 2008 May
TI  - Emergence of an egocentric cue guiding and allocentric inferring strategy that 
      mirrors hippocampal brain-derived neurotrophic factor (BDNF) expression in the 
      Morris water maze.
PG  - 462-79
AB  - From insects to humans, successful navigation relies on retained representations 
      of spatial relations. These representations are thought to depend on the 
      hippocampal formation, particularly those that are independent of the navigator 
      (allocentric representations). The Morris water maze is a simple and popular task 
      often used to assess spatial navigation. But how animals navigate toward and 
      retain information regarding the location of the goal in this task remains 
      unclear. We provide a comprehensive account of how the water maze is accomplished 
      behaviourally. Our findings suggest that animals solve the task using distal cues 
      via an initial view-matching strategy that is supported by egocentric guidance. 
      Through increased training, however, an emergence of an egocentric-guiding 
      strategy combined with the animal's greater ability to infer the hidden 
      platform's location (via allocentric extrapolation) emerges. We also demonstrate 
      that behavioural changes, towards a more allocentric strategy, are reflected in 
      increases in hippocampal brain-derived neurotrophic factor.
FAU - Harvey, Deirdre R
AU  - Harvey DR
AD  - Department of Psychology, National University of Ireland-Maynooth, Maynooth, Co. 
      Kildare, Ireland.
FAU - McGauran, Anne-Marie T
AU  - McGauran AM
FAU - Murphy, Jonathan
AU  - Murphy J
FAU - Burns, Lauren
AU  - Burns L
FAU - McMonagle, Eoghan
AU  - McMonagle E
FAU - Commins, Sean
AU  - Commins S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071017
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/physiology
MH  - Entorhinal Cortex/physiology
MH  - Head Movements/physiology
MH  - Hippocampus/*physiology
MH  - Immunoassay
MH  - Male
MH  - Maze Learning/*physiology
MH  - Orientation/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Space Perception/*physiology
MH  - Swimming/physiology
MH  - Water
EDAT- 2007/10/10 09:00
MHDA- 2008/07/17 09:00
CRDT- 2007/10/10 09:00
PHST- 2007/06/20 00:00 [received]
PHST- 2007/08/23 00:00 [revised]
PHST- 2007/08/24 00:00 [accepted]
PHST- 2007/10/10 09:00 [pubmed]
PHST- 2008/07/17 09:00 [medline]
PHST- 2007/10/10 09:00 [entrez]
AID - S1074-7427(07)00139-6 [pii]
AID - 10.1016/j.nlm.2007.08.013 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2008 May;89(4):462-79. doi: 10.1016/j.nlm.2007.08.013. Epub 
      2007 Oct 17.