PMID- 17923546
OWN - NLM
STAT- MEDLINE
DCOM- 20071025
LR  - 20220317
IS  - 0003-9950 (Print)
IS  - 0003-9950 (Linking)
VI  - 125
IP  - 10
DP  - 2007 Oct
TI  - Human leukocyte antigen B27 and B51 double-positive Behcet uveitis.
PG  - 1375-80
AB  - OBJECTIVES: To describe the clinical characteristics of human leukocyte antigen 
      (HLA) B27 and B51 double-positive Behcet uveitis and to determine whether the 
      coexistence of HLA-B27 can affect Behcet uveitis. METHODS: We retrospectively 
      reviewed the medical records of patients with Behcet uveitis and patients with 
      HLA-B27-associated non-Behcet uveitis who underwent HLA-B27 and HLA-B51 typing 
      and were followed up for more than 3 years. We divided the patients into 3 groups 
      according to HLA-B27/B51 status and compared the clinical outcomes. Main outcome 
      measures were demographic features, uveitis characteristics, complications, 
      treatments, and visual prognosis. RESULTS: Fourteen patients with 
      HLA-B27(+)B51(+) Behcet uveitis, 43 patients with HLA-B27(-)B51(+) Behcet 
      uveitis, and 41 patients with HLA-B27(+)B51(-) non-Behcet uveitis were 
      identified. HLA-B27(+)B51(+) Behcet uveitis showed the demographic features 
      similar to HLA-B27(-) counterparts. However, HLA-B27(+)B51(+) Behcet uveitis 
      showed less involvement of posterior segments, a less chronic course, fewer 
      complications in posterior segments, and less use of systemic medication or 
      surgical intervention for inflammatory control, similar to HLA-B27(+)B51(-) 
      non-Behcet uveitis. The long-term vision prognosis of HLA-B27(+)B51(+) Behcet 
      uveitis was more favorable than that of HLA-B27(-)B51(+) Behcet uveitis. 
      CONCLUSIONS: Our results indicate that HLA-B27(+)B51(+) Behcet uveitis is a 
      benign subgroup of Behcet uveitis. The positivity of HLA-B27 may be a good 
      prognostic factor in Behcet uveitis.
FAU - Ahn, Jae Kyoun
AU  - Ahn JK
AD  - Department of Ophthalmology, Chonnam National University Medical School, 8 
      Hakdong, Donggu, Gwangju 501-757, Korea. jkahn@jnu.ac.kr
FAU - Park, Yeoung Geol
AU  - Park YG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Ophthalmol
JT  - Archives of ophthalmology (Chicago, Ill. : 1960)
JID - 7706534
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Behcet Syndrome/diagnosis/drug therapy/*immunology
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - HLA-B Antigens/*immunology
MH  - HLA-B27 Antigen/*immunology
MH  - HLA-B51 Antigen
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Uveitis/diagnosis/drug therapy/*immunology
EDAT- 2007/10/10 09:00
MHDA- 2007/10/27 09:00
CRDT- 2007/10/10 09:00
PHST- 2007/10/10 09:00 [pubmed]
PHST- 2007/10/27 09:00 [medline]
PHST- 2007/10/10 09:00 [entrez]
AID - 125/10/1375 [pii]
AID - 10.1001/archopht.125.10.1375 [doi]
PST - ppublish
SO  - Arch Ophthalmol. 2007 Oct;125(10):1375-80. doi: 10.1001/archopht.125.10.1375.