PMID- 17923754
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20211020
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 22 Suppl
IP  - Suppl
DP  - 2007 Sep
TI  - High frequency of genetic alterations in non-small cell lung cancer detected by 
      multi-target fluorescence in situ hybridization.
PG  - S47-51
AB  - Detection of genetic alterations could provide a tool as an adjuvant for the 
      diagnosis of non-small cell lung cancer (NSCLC) and to define patients at risk 
      for early relapse. In this study, a multi-target fluorescence in situ 
      hybridization (FISH) assay was conducted to investigate the correlation between 
      the alterations of chromosomes, including 5p15.2, 6p11.1-q11, 7p12, and 
      8q24.12-q24.13 (LaVysion Test), and clinicopathological variables, and to clarify 
      the potential of the multi-target FISH assay in 37 NSCLC. The most notable 
      finding was the higher frequency of a gain in chromosome 5p15.2 in early-stage 
      (I+IIa) lung cancers. The frequency of the gain was 81.3% (16/22) in stage I 
      tumors. The frequencies of gains in 6p11.1-q11 and 8q24.12-q24.13 were 61.5% 
      (8/13) and 84.6% (11/13) in stage IIIa cancers, as compared with lower 
      frequencies in stage I tumors at 25.0% and 31.3%, respectively. There was also a 
      significant difference in the histological type. Our results suggest that a gain 
      in 6p11.1-q11 and 8q24.12-q24.13 plays an important role in tumor progression and 
      is associated with histological differentiation. On the other hand, gene 
      amplification in the 5p region was one of the most consistent alterations in 
      early-stage lung cancer, and thus a series of genes in the critical 5p15.2 region 
      might potentially associated with the development of lung cancer.
FAU - Kang, Ji Un
AU  - Kang JU
AD  - Department of Laboratory Medicine, Chungnam National University Hospital, 
      Daejeon, Korea.
FAU - Koo, Sun Hoe
AU  - Koo SH
FAU - Kwon, Kye Chul
AU  - Kwon KC
FAU - Park, Jong Woo
AU  - Park JW
FAU - Shin, So Youn
AU  - Shin SY
FAU - Kim, Jin Man
AU  - Kim JM
FAU - Jung, Sung Su
AU  - Jung SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/*genetics/pathology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 5/genetics
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/diagnosis/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
PMC - PMC2694384
EDAT- 2007/12/06 09:00
MHDA- 2008/01/23 09:00
PMCR- 2007/09/01
CRDT- 2007/12/06 09:00
PHST- 2007/12/06 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/12/06 09:00 [entrez]
PHST- 2007/09/01 00:00 [pmc-release]
AID - 200709s047 [pii]
AID - 10.3346/jkms.2007.22.S.S47 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2007 Sep;22 Suppl(Suppl):S47-51. doi: 
      10.3346/jkms.2007.22.S.S47.