PMID- 17924851
OWN - NLM
STAT- MEDLINE
DCOM- 20080117
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 10
DP  - 2007
TI  - Diagnostic usefulness of a third-generation anti-cyclic citrulline antibody test 
      in patients with recent-onset polyarthritis.
PG  - 1396-401
AB  - BACKGROUND: The high specificity of anti-cyclic citrullinated peptide antibodies 
      (anti-CCP) helps substantially in the diagnosis of rheumatoid arthritis (RA), 
      combined with classical markers such as rheumatoid factor (RF). The recent 
      introduction of third-generation methods (anti-CCP3) for anti-CCP detection could 
      further improve diagnostic efficiency. The aim of this study was to determinate 
      the diagnostic efficiency (sensitivity and specificity) of anti-CCP using a new 
      anti-CCP3 method and to compare it with the previous second-generation method 
      (anti-CCP2). METHODS: Anti-CCP were studied in sera of 234 patients with 
      recent-onset polyarthritis (ROP) (age > or =16 years; evolution time > or =4 
      weeks < or =1 year; 2 or more inflamed joints, without drug therapy). After 1 
      year, 124 patients were diagnosed with RA (American College of Rheumatology 
      criteria). Two ELISAs, an anti-CCP2 and an anti-CCP3, were performed. RESULTS: 
      The best sensitivity according to receiver operating characteristic curves was 
      51.5% and 54.8% for anti-CCP3 and anti-CCP2, with a specificity of 96.2% and 
      98.1%, respectively (optimal cutoffs 14.2 and 18.7 U/mL). Significant 
      correlations were obtained (p<0.001) when the methods were compared to each other 
      and to RF. CONCLUSIONS: Testing with both types of anti-CCP kit is highly 
      specific for the presence of RA. In our ROP group, anti-CCP2 and anti-CCP3 
      exhibited similar diagnostic efficiency.
FAU - Luis Caro-Oleas, Jose
AU  - Luis Caro-Oleas J
AD  - Department of Immunology, University Hospital Virgen del Rocio, Sevilla, Spain. 
      joseluiscaro@hotmail.com
FAU - Fernandez-Suarez, Antonio
AU  - Fernandez-Suarez A
FAU - Reneses Cesteros, Sonsoles
AU  - Reneses Cesteros S
FAU - Porrino, Carmen
AU  - Porrino C
FAU - Nunez-Roldan, Antonio
AU  - Nunez-Roldan A
FAU - Wichmann Schlipf, Ingeborg
AU  - Wichmann Schlipf I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Arthritis/*diagnosis/*immunology
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptides, Cyclic/*immunology
MH  - Rheumatoid Factor/*blood
MH  - Sensitivity and Specificity
EDAT- 2007/10/11 09:00
MHDA- 2008/01/18 09:00
CRDT- 2007/10/11 09:00
PHST- 2007/10/11 09:00 [pubmed]
PHST- 2008/01/18 09:00 [medline]
PHST- 2007/10/11 09:00 [entrez]
AID - 10.1515/CCLM.2007.294 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(10):1396-401. doi: 10.1515/CCLM.2007.294.