PMID- 17925604
OWN - NLM
STAT- MEDLINE
DCOM- 20080114
LR  - 20171116
IS  - 0954-6928 (Print)
IS  - 0954-6928 (Linking)
VI  - 18
IP  - 7
DP  - 2007 Nov
TI  - CD14+ monocyte levels in subgroups of acute coronary syndromes.
PG  - 519-22
AB  - OBJECTIVES: We aimed to investigate whether there were any differences in the 
      percentages of CD14(+) monocytes between subgroups of acute coronary syndromes 
      (ACS). CD14(+) is a monocyte surface receptor that plays a role in the innate 
      immune system. CD14(+) monocytes are associated with complications of 
      atherosclerosis. METHODS: In total we enrolled 115 patients with ACS: 24 with 
      unstable angina (UA); 29 with non-ST elevation myocardial infarction (NSTEMI); 
      and 62 with ST elevation myocardial infarction (STEMI). The levels of C-reactive 
      protein and percentage of CD14(+) monocyte were measured on admission. RESULTS: 
      CD14(+) monocyte percentages were observed to be different between groups by 
      analysis of variance test. The percentages of CD14(+) monocyte were 
      81.24+/-10.04% in the UA group; 89.40+/-5.84% in the NSTEMI group; and 
      87.22+/-11.75% in the STEMI group (P=0.013). The differences between the UA and 
      the NSTEMI and between the UA and the STEMI groups with Bonferroni posthoc 
      testing were significant (P=0.014 and P=0.049 respectively). Moreover, no 
      significant difference was found between the NSTEMI and STEMI groups (P=1.000). 
      The C-reactive protein levels in the UA group were detected to be significantly 
      low with Bonferroni posthoc testing compared with both the NSTEMI and STEMI 
      groups (for both comparisons, P<0.002). CONCLUSIONS: A significant difference in 
      CD14(+) monocyte percentages between subgroups of ACS was determined. CD14(+) 
      monocyte percentages can be a useful parameter in differentiating between the 
      subgroups of ACS, especially between UA and myocardial infarction.
FAU - Ozdogru, Ibrahim
AU  - Ozdogru I
AD  - Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey. 
      iozdogru@erciyes.edu.tr
FAU - Inanc, Mehmet Tugrul
AU  - Inanc MT
FAU - Eryol, Namk Kemal
AU  - Eryol NK
FAU - Dogan, Ali
AU  - Dogan A
FAU - Kaya, Mehmet Gungor
AU  - Kaya MG
FAU - Gul, Ibrahim
AU  - Gul I
FAU - Kalay, Nihat
AU  - Kalay N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Coronary Syndrome/*blood/*metabolism
MH  - Aged
MH  - Atherosclerosis/complications
MH  - C-Reactive Protein/biosynthesis
MH  - Cardiology/methods
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Lipopolysaccharide Receptors/*biosynthesis
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Monocytes/metabolism
MH  - Myocardial Infarction/*blood/metabolism
MH  - Treatment Outcome
EDAT- 2007/10/11 09:00
MHDA- 2008/01/15 09:00
CRDT- 2007/10/11 09:00
PHST- 2007/10/11 09:00 [pubmed]
PHST- 2008/01/15 09:00 [medline]
PHST- 2007/10/11 09:00 [entrez]
AID - 00019501-200711000-00003 [pii]
AID - 10.1097/MCA.0b013e3282ef4e7c [doi]
PST - ppublish
SO  - Coron Artery Dis. 2007 Nov;18(7):519-22. doi: 10.1097/MCA.0b013e3282ef4e7c.