PMID- 17925918
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20131121
IS  - 1841-8724 (Print)
IS  - 1841-8724 (Linking)
VI  - 16
IP  - 3
DP  - 2007 Sep
TI  - Management of nonfunctioning pancreatic endocrine tumors in the context of 
      multiple endocrine neoplasia type 1 syndrome.
PG  - 257-62
AB  - The aim of our study is to present our experience in the surgical treatment of 
      nonfunctioning pancreatic endocrine tumors (NFPETs) in patients with multiple 
      endocrine neoplasia type 1 (MEN-1). PATIENTS AND METHOD: Between 1996 and 2006 a 
      total of 11 patients with clinically confirmed MEN 1 syndrome were monitored in 
      an annual screening program that included evaluation of the pancreas. Our policy 
      was to use Computed Tomography (CT), Magnetic Resonance Imaging (MRI) and 
      Endoscopic Ultrasound (EUS) in combination with biochemical screening in an 
      effort to early diagnose and categorize the pancreatic involvement in MEN-1. 
      RESULTS: NFPETs were identified in 4 female patients (36.4%). Diagnosis of NFPET 
      was established 4.2 years later than that of MEN 1. The median tumor diameter at 
      diagnosis was 2.2 cm (range 1.8-2.6 cm). All patients were treated by distal 
      pancreatectomy. Diagnosis of NFPET was established in histological sections by 
      staining with neuroendocrine tumor markers. Adjuvant therapy with streptozocin in 
      combination with 5-fluorouracil was applied in two patients. After surgery the 
      patients were followed up annually with clinical evaluation, biochemical tests 
      and imaging studies. CONCLUSIONS: Early detection of NFPETs in patients with 
      MEN-1 syndrome can be accomplished by biochemical and radiological screening 
      program. NFPETs should be removed when diagnosed, in order to achieve a timely 
      and efficient prophylaxis against further tumor growth and malignant development.
FAU - Botsios, Dimitrios
AU  - Botsios D
AD  - 4th Surgical Department, Aristotle University, Exohi 570 10, Thessaloniki, 
      Greece.
FAU - Vasiliadis, Konstantinos
AU  - Vasiliadis K
FAU - Tsalis, Konstantinos
AU  - Tsalis K
FAU - Iordanidis, Fotis
AU  - Iordanidis F
FAU - Megalopoulos, Angelos
AU  - Megalopoulos A
FAU - Tsachalis, Theodoros
AU  - Tsachalis T
FAU - Blouhos, Konstantinos
AU  - Blouhos K
FAU - Betsis, Dimitrios
AU  - Betsis D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Romania
TA  - J Gastrointestin Liver Dis
JT  - Journal of gastrointestinal and liver diseases : JGLD
JID - 101272825
RN  - 5W494URQ81 (Streptozocin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
CIN - J Gastrointestin Liver Dis. 2007 Sep;16(3):295-6. PMID: 17925925
MH  - Adolescent
MH  - Adult
MH  - Chemotherapy, Adjuvant
MH  - Drug Therapy, Combination
MH  - Endosonography
MH  - Female
MH  - Fluorouracil/administration & dosage/therapeutic use
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/drug therapy/pathology/*surgery
MH  - Pancreas/pathology
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/diagnosis/drug therapy/pathology/*surgery
MH  - Streptozocin/administration & dosage/therapeutic use
MH  - Time Factors
MH  - Tomography, X-Ray Computed
EDAT- 2007/10/11 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/11 09:00
PHST- 2007/10/11 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/11 09:00 [entrez]
AID - 4 [pii]
PST - ppublish
SO  - J Gastrointestin Liver Dis. 2007 Sep;16(3):257-62.