PMID- 17927973
OWN - NLM
STAT- MEDLINE
DCOM- 20080324
LR  - 20161124
IS  - 1095-564X (Electronic)
IS  - 0012-1606 (Linking)
VI  - 311
IP  - 2
DP  - 2007 Nov 15
TI  - Menin is required in cranial neural crest for palatogenesis and perinatal 
      viability.
PG  - 524-37
AB  - Menin is a nuclear protein encoded by a tumor suppressor gene that is mutated in 
      humans with multiple endocrine neoplasia type 1 (MEN1). Menin functions as a 
      component of a histone methyltransferase complex that regulates expression of 
      target genes including the cell cycle inhibitor p27(kip1). Here, we show that 
      menin plays a previously unappreciated and critical role in cranial neural crest. 
      Tissue-specific inactivation of menin in Pax3- or Wnt1-expressing neural crest 
      cells leads to perinatal death, cleft palate and other cranial bone defects, 
      which are associated with a decrease in p27(kip1) expression. Deletion of menin 
      in Pax3-expressing somite precursors also produces patterning defects of rib 
      formation. Thus, menin functions in vivo during osteogenesis and is required for 
      palatogenesis, skeletal rib formation and perinatal viability.
FAU - Engleka, Kurt A
AU  - Engleka KA
AD  - Department of Cell and Developmental Biology and the Cardiovascular Institute, 
      University of Pennsylvania, 1154 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, 
      USA.
FAU - Wu, Meilin
AU  - Wu M
FAU - Zhang, Maozhen
AU  - Zhang M
FAU - Antonucci, Nicole B
AU  - Antonucci NB
FAU - Epstein, Jonathan A
AU  - Epstein JA
LA  - eng
GR  - R01 HL 61475/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070907
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Men1 protein, mouse)
RN  - 0 (PAX3 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt1 Protein)
RN  - 0 (Wnt1 protein, mouse)
RN  - 138016-91-8 (Pax3 protein, mouse)
SB  - IM
MH  - Abnormalities, Multiple/genetics/pathology
MH  - Animals
MH  - Animals, Newborn
MH  - Cells, Cultured
MH  - Cleft Palate
MH  - *Fetal Mortality
MH  - Humans
MH  - Mice
MH  - Mice, Transgenic
MH  - *Morphogenesis
MH  - Neural Crest/*metabolism
MH  - PAX3 Transcription Factor
MH  - Paired Box Transcription Factors/genetics/metabolism
MH  - *Palate/embryology/growth & development
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Wnt1 Protein/genetics/metabolism
EDAT- 2007/10/12 09:00
MHDA- 2008/03/25 09:00
CRDT- 2007/10/12 09:00
PHST- 2007/07/06 00:00 [received]
PHST- 2007/08/24 00:00 [revised]
PHST- 2007/08/30 00:00 [accepted]
PHST- 2007/10/12 09:00 [pubmed]
PHST- 2008/03/25 09:00 [medline]
PHST- 2007/10/12 09:00 [entrez]
AID - S0012-1606(07)01319-X [pii]
AID - 10.1016/j.ydbio.2007.08.057 [doi]
PST - ppublish
SO  - Dev Biol. 2007 Nov 15;311(2):524-37. doi: 10.1016/j.ydbio.2007.08.057. Epub 2007 
      Sep 7.