PMID- 17927990
OWN - NLM
STAT- MEDLINE
DCOM- 20081118
LR  - 20211020
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 54
IP  - 1
DP  - 2008 Jun
TI  - Effects of multiparity on recognition memory, monoaminergic neurotransmitters, 
      and brain-derived neurotrophic factor (BDNF).
PG  - 7-17
AB  - Recognition memory and anxiety were examined in nulliparous (NP: 0 litters) and 
      multiparous (MP: 5-6 litters) middle-aged female rats (12 months old) to assess 
      possible enduring effects of multiparity at least 3 months after the last litter 
      was weaned. MP females performed significantly better than NP females on the 
      non-spatial memory task, object recognition, and the spatial memory task, object 
      placement. Anxiety as measured on the elevated plus maze did not differ between 
      groups. Monoaminergic activity and levels were measured in prefrontal cortex, CA1 
      hippocampus, CA3 hippocampus, and olfactory bulb (OB). NP and MP females differed 
      in monoamine concentrations in the OB only, with MP females having significantly 
      greater concentrations of dopamine and metabolite DOPAC, norepinephrine and 
      metabolite MHPG, and the serotonin metabolite 5-HIAA, as compared to NP females. 
      These results indicate a long-term change in OB neurochemistry as a result of 
      multiparity. Brain-derived neurotrophic factor (BDNF) was also measured in 
      hippocampus (CA1, CA3, dentate gyrus) and septum. MP females had higher BDNF 
      levels in both CA1 and septum; as these regions are implicated in memory 
      performance, elevated BDNF may underlie the observed memory task differences. 
      Thus, MP females (experiencing multiple bouts of pregnancy, birth, and pup 
      rearing during the first year of life) displayed enhanced memory task performance 
      but equal anxiety responses, as compared to NP females. These results are 
      consistent with previous studies showing long-term changes in behavioral function 
      in MP, as compared to NP, rats and suggest that alterations in monoamines and a 
      neurotrophin, BDNF, may contribute to the observed behavioral changes.
FAU - Macbeth, Abbe H
AU  - Macbeth AH
AD  - Department of Psychology, Hunter College, CUNY, New York, NY 10021, USA. 
      macbetha@mail.nih.gov
FAU - Scharfman, Helen E
AU  - Scharfman HE
FAU - Maclusky, Neil J
AU  - Maclusky NJ
FAU - Gautreaux, Claris
AU  - Gautreaux C
FAU - Luine, Victoria N
AU  - Luine VN
LA  - eng
GR  - S06 GM060654/GM/NIGMS NIH HHS/United States
GR  - S06 GM060654-070015/GM/NIGMS NIH HHS/United States
GR  - R25 GM060665/GM/NIGMS NIH HHS/United States
GR  - G12 RR003037-22/RR/NCRR NIH HHS/United States
GR  - NS 37562/NS/NINDS NIH HHS/United States
GR  - S06 GM060654-08/GM/NIGMS NIH HHS/United States
GR  - RR-03037/RR/NCRR NIH HHS/United States
GR  - G12 RR003037/RR/NCRR NIH HHS/United States
GR  - S06-GM-60654/GM/NIGMS NIH HHS/United States
GR  - R56 NS037562/NS/NINDS NIH HHS/United States
GR  - R01 NS037562-08/NS/NINDS NIH HHS/United States
GR  - R01 NS037562/NS/NINDS NIH HHS/United States
GR  - R25 GM060665-08/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070831
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Neurotransmitter Transport Proteins)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Biogenic Monoamines/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Gonadal Steroid Hormones/blood
MH  - Hippocampus/metabolism
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - Neurotransmitter Transport Proteins/metabolism/*physiology
MH  - Parity/*physiology
MH  - Pattern Recognition, Physiological/*physiology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred F344
MH  - Rats, Sprague-Dawley
MH  - Septum of Brain/metabolism
PMC - PMC2441760
MID - NIHMS54372
EDAT- 2007/10/12 09:00
MHDA- 2008/11/19 09:00
PMCR- 2009/06/01
CRDT- 2007/10/12 09:00
PHST- 2007/04/16 00:00 [received]
PHST- 2007/08/20 00:00 [revised]
PHST- 2007/08/22 00:00 [accepted]
PHST- 2007/10/12 09:00 [pubmed]
PHST- 2008/11/19 09:00 [medline]
PHST- 2007/10/12 09:00 [entrez]
PHST- 2009/06/01 00:00 [pmc-release]
AID - S0018-506X(07)00205-X [pii]
AID - 10.1016/j.yhbeh.2007.08.011 [doi]
PST - ppublish
SO  - Horm Behav. 2008 Jun;54(1):7-17. doi: 10.1016/j.yhbeh.2007.08.011. Epub 2007 Aug 
      31.