PMID- 17928143
OWN - NLM
STAT- MEDLINE
DCOM- 20080125
LR  - 20091119
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 427
IP  - 1
DP  - 2007 Oct 29
TI  - No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder 
      in the Korean population.
PG  - 1-5
AB  - It has been suggested that bipolar disorder is associated with altered immune 
      function. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that 
      influences both neural and immune functions. We thus hypothesized that MCP-1 may 
      be related to the development or pathophysiology of bipolar disorder. In this 
      case-control study, we investigated the association between the A-2518G single 
      nucleotide polymorphism (SNP) of the MCP-1 promoter and bipolar disorder. 
      Patients with bipolar disorder (n=183; bipolar I=145, bipolar II=38) and healthy 
      controls (350) were recruited for the study. No significant allelic or genotypic 
      association was detected between the A-2518G polymorphism and any sample of 
      bipolar disorder patients. When we pooled the healthy controls and the cases of 
      bipolar I disorder from previous Korean studies and this study, we again found no 
      significant association. No significant difference in either allele frequency or 
      genotype distribution was observed between bipolar I and bipolar II disorders. 
      There was no difference in the age at onset of bipolar disorder among the three 
      genotype groups. Our data suggest that the A-2518G polymorphism of MCP-1 is not a 
      major susceptibility factor for bipolar disorder in the Korean population. 
      However, the physiological role of MCP-1 is highly suggestive of its being 
      associated with bipolar disorder, and further analyses of other SNPs of MCP-1 
      remain to be performed.
FAU - Roh, Myoung-Sun
AU  - Roh MS
AD  - Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, 
      Republic of Korea.
FAU - Lee, Kyu Young
AU  - Lee KY
FAU - Joo, Eun-Jeong
AU  - Joo EJ
FAU - Lee, Namyoung
AU  - Lee N
FAU - Kim, Yong Sik
AU  - Kim YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070421
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Bipolar Disorder/ethnology/*genetics/metabolism
MH  - Brain/metabolism/physiopathology
MH  - Brain Chemistry/*genetics
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Korea/ethnology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2007/10/12 09:00
MHDA- 2008/01/26 09:00
CRDT- 2007/10/12 09:00
PHST- 2007/02/21 00:00 [received]
PHST- 2007/04/05 00:00 [revised]
PHST- 2007/04/18 00:00 [accepted]
PHST- 2007/10/12 09:00 [pubmed]
PHST- 2008/01/26 09:00 [medline]
PHST- 2007/10/12 09:00 [entrez]
AID - S0304-3940(07)00482-X [pii]
AID - 10.1016/j.neulet.2007.04.038 [doi]
PST - ppublish
SO  - Neurosci Lett. 2007 Oct 29;427(1):1-5. doi: 10.1016/j.neulet.2007.04.038. Epub 
      2007 Apr 21.