PMID- 17928585
OWN - NLM
STAT- MEDLINE
DCOM- 20071120
LR  - 20220311
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 87
IP  - 4
DP  - 2007 Oct
TI  - Myocardial matrix remodeling and the matrix metalloproteinases: influence on 
      cardiac form and function.
PG  - 1285-342
AB  - It is now becoming apparent that dynamic changes occur within the interstitium 
      that directly contribute to adverse myocardial remodeling following myocardial 
      infarction (MI), with hypertensive heart disease and with intrinsic myocardial 
      disease such as cardiomyopathy. Furthermore, a family of matrix proteases, the 
      matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs), has 
      been recognized to play an important role in matrix remodeling in these cardiac 
      disease states. The purpose of this review is fivefold: 1) to examine and 
      redefine the myocardial matrix as a critical and dynamic entity with respect to 
      the remodeling process encountered with MI, hypertension, or cardiomyopathic 
      disease; 2) present the remarkable progress that has been made with respect to 
      MMP/TIMP biology and how it relates to myocardial matrix remodeling; 3) to 
      evaluate critical translational/clinical studies that have provided a 
      cause-effect relationship between alterations in MMP/TIMP regulation and 
      myocardial matrix remodeling; 4) to provide a critical review and analysis of 
      current diagnostic, prognostic, and pharmacological approaches that utilized our 
      basic understanding of MMP/TIMPs in the context of cardiac disease; and 5) most 
      importantly, to dispel the historical belief that the myocardial matrix is a 
      passive structure and supplant this belief that the regulation of matrix protease 
      pathways such as the MMPs and TIMPs will likely yield a new avenue of diagnostic 
      and therapeutic strategies for myocardial remodeling and the progression to heart 
      failure.
FAU - Spinale, Francis G
AU  - Spinale FG
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 
      Charleston, South Carolina 29403, USA.
LA  - eng
GR  - HL-59165/HL/NHLBI NIH HHS/United States
GR  - P01-HL-48788-08/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix/*enzymology/physiology
MH  - Gene Expression/physiology
MH  - Heart/anatomy & histology/physiology
MH  - Heart Diseases/enzymology/pathology/physiopathology
MH  - Humans
MH  - Matrix Metalloproteinases/genetics/*metabolism
MH  - Myocardium/*enzymology
MH  - Ventricular Remodeling/*physiology
RF  - 547
EDAT- 2007/10/12 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/10/12 09:00
PHST- 2007/10/12 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/10/12 09:00 [entrez]
AID - 87/4/1285 [pii]
AID - 10.1152/physrev.00012.2007 [doi]
PST - ppublish
SO  - Physiol Rev. 2007 Oct;87(4):1285-342. doi: 10.1152/physrev.00012.2007.