PMID- 17931105
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20220408
IS  - 0882-8245 (Print)
IS  - 0882-8245 (Linking)
VI  - 20
IP  - 3
DP  - 2007 Sep
TI  - Genetic perspectives on host responses to porcine reproductive and respiratory 
      syndrome (PRRS).
PG  - 343-58
AB  - Porcine reproductive and respiratory syndrome (PRRS) is the most economically 
      important disease in pig populations, worldwide. Current research, both in vitro 
      and in vivo, has failed to provide industry with a reliable or effective method 
      to combat the disease. In this paper the present knowledge of the genetics of the 
      host response to porcine reproductive and respiratory syndrome virus (PRRSV) is 
      reviewed. Special reference is made to clinical signs of disease, in vitro and in 
      vivo studies, and evidence of genetic variation in host response to the disease. 
      It is concluded that although clinical signs are numerous, and in vitro and in 
      vivo studies often fail to yield comparable results, there is sufficient evidence 
      of genetic variation in host responses to infection to examine the possibility of 
      breeding for enhanced resistance or tolerance. Advances in genomics have allowed 
      examination of changes in gene expression in response to infection to be examined 
      in tandem with genomewide linkage disequilibrium scans. These advances could 
      allow the possibility for commercial breeding programs to be established, 
      selecting for PRRS resistance or tolerance. When breeding for resistance to one 
      disease, such as PRRS, it could be postulated that the viral control mechanism 
      being exploited could have beneficial effects on resistance to other viral 
      diseases in pigs if, for example, the mechanisms act on primary immune pathways 
      associated with viral replication. Conversely, however, selection for disease 
      resistance could facilitate an increase in susceptibility to other diseases or a 
      reduction in overall productivity. Extensive data recording may be required to 
      guard against such possibilities. Overall, breeding for disease control in pigs 
      is an underutilized tool that could have desirable long-term effects in breeding 
      programs. More research is needed to examine the possible pathways of PRRS 
      resistance so that viable control methods can be found to ease the disease burden 
      and thus increase animal welfare and economic viability.
FAU - Lewis, Craig R G
AU  - Lewis CR
AD  - Division of Genetics and Genomics, Roslin Institute (Edinburgh), Roslin, 
      Midlothian, United Kingdom. craig.lewis@bbsrc.ac.uk
FAU - Ait-Ali, Tahar
AU  - Ait-Ali T
FAU - Clapperton, Mary
AU  - Clapperton M
FAU - Archibald, Alan L
AU  - Archibald AL
FAU - Bishop, Stephen
AU  - Bishop S
LA  - eng
GR  - EGA16307/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
SB  - IM
MH  - Animals
MH  - *Genetic Variation
MH  - Immunity, Innate/genetics
MH  - Porcine Reproductive and Respiratory Syndrome/*genetics/physiopathology
MH  - Swine
MH  - Swine Diseases/*genetics/physiopathology
RF  - 124
EDAT- 2007/10/13 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/13 09:00
PHST- 2007/10/13 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/13 09:00 [entrez]
AID - 10.1089/vim.2007.0024 [doi]
PST - ppublish
SO  - Viral Immunol. 2007 Sep;20(3):343-58. doi: 10.1089/vim.2007.0024.