PMID- 17931209
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20200930
IS  - 1386-6346 (Print)
IS  - 1386-6346 (Linking)
VI  - 37 Suppl 3
DP  - 2007 Oct
TI  - Autoimmune hepatitis in childhood.
PG  - S496-500
AB  - Autoimmune hepatitis (AIH) is a generally progressive inflammatory liver disease 
      of unknown etiology that occurs in adults and children. Although the peak age of 
      incidence is in prepubertal girls, AIH has been diagnosed as early 6 months of 
      age. Two types of AIH are recognized according to the nature of the autoantibody 
      detected in children at the time of diagnosis. The diagnosis of AIH is based on 
      histological abnormalities, characteristic clinical and biochemical findings, and 
      abnormal levels of serum globulin due almost exclusively to markedly increased 
      immunoglobulin G including various autoantibodies. A genetic predisposition is 
      suggested by the increase frequency of human leukocyte antigen (HLA) haplotypes 
      HLA-B8/DR3, and allotypes DR3 and DR4. However, the incidence of these HLA types 
      is different in each country.Proposed triggers of AIH that may initiate the 
      inflammatory process include some viral infections and some drugs. There is much 
      information about adults with AIH, however, little information on AIH in 
      children, especially in Japanese children. To clarify the clinicohistological 
      features of AIH in Japanese children, we analyzed the clinical, pathological 
      features and response to treatment in 12 Japanese children with AIH. Furthermore, 
      we discuss several problems for diagnosis and treatment for AIH in children.
FAU - Fujisawa, Tomoo
AU  - Fujisawa T
AD  - Children's Center for Health and Development, Yokohama City Tobu Hospital, 
      Yokohama, Japan.
FAU - Sogo, Tsuyoshi
AU  - Sogo T
FAU - Komatsu, Haruki
AU  - Komatsu H
FAU - Inui, Ayano
AU  - Inui A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hepatol Res
JT  - Hepatology research : the official journal of the Japan Society of Hepatology
JID - 9711801
EDAT- 2007/10/13 09:00
MHDA- 2007/10/13 09:01
CRDT- 2007/10/13 09:00
PHST- 2007/10/13 09:00 [pubmed]
PHST- 2007/10/13 09:01 [medline]
PHST- 2007/10/13 09:00 [entrez]
AID - HEP248 [pii]
AID - 10.1111/j.1872-034X.2007.00248.x [doi]
PST - ppublish
SO  - Hepatol Res. 2007 Oct;37 Suppl 3:S496-500. doi: 10.1111/j.1872-034X.2007.00248.x.