PMID- 17933217
OWN - NLM
STAT- MEDLINE
DCOM- 20071109
LR  - 20211020
IS  - 1052-2166 (Print)
IS  - 1555-3884 (Electronic)
IS  - 1052-2166 (Linking)
VI  - 14
IP  - 1
DP  - 2007
TI  - Gene expression variability in subcutaneous and omental adipose tissue of obese 
      men.
PG  - 35-46
AB  - We investigated interindividual variability in gene expression in abdominal 
      subcutaneous (SC) and omental (OM) adipose tissue of 10 massively obese men. 
      Affymetrix human U133A microarrays were used to measure gene expression levels. A 
      total of 6811 probesets generated significant signal in both depots in all 
      samples. Interindividual variability in gene expression was rather low, with more 
      than 90% of transcripts showing a coefficient of variation (CV) lower than 23.6% 
      and 21.7% in OM and SC adipose tissues, respectively. The distributions of CV 
      were similar between the two fat depots. A set of highly variable genes was 
      identified for both tissues on the basis of a high CV and elevated gene 
      expression level. Among the set of highly regulated genes, 18 transcripts were 
      involved in lipid metabolism and 28 transcripts were involved in cell death for 
      SC and OM samples, respectively. In conclusion, gene expression interindividual 
      variability was rather low and globally similar between fat compartments, and the 
      adipose tissue transcriptome appeared as relatively stable, although specific 
      pathways were found to be highly variable in SC and OM depots.
FAU - Zhang, Yonghua
AU  - Zhang Y
AD  - Molecular Endocrinology and Oncology Research Center, Laval University Medical 
      Research Center, Quebec, Canada.
FAU - Bosse, Yohan
AU  - Bosse Y
FAU - Marceau, Picard
AU  - Marceau P
FAU - Biron, Simon
AU  - Biron S
FAU - Lebel, Stephan
AU  - Lebel S
FAU - Richard, Denis
AU  - Richard D
FAU - Vohl, Marie-Claude
AU  - Vohl MC
FAU - Tchernof, Andre
AU  - Tchernof A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Gene Expr
JT  - Gene expression
JID - 9200651
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Cell Death/genetics
MH  - *Gene Expression
MH  - *Genetic Variation
MH  - Humans
MH  - Lipid Metabolism/genetics
MH  - Male
MH  - Microarray Analysis
MH  - *Obesity
MH  - Omentum
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Subcutaneous Fat/*metabolism
PMC - PMC6042019
EDAT- 2007/10/16 09:00
MHDA- 2007/11/10 09:00
PMCR- 2018/07/12
CRDT- 2007/10/16 09:00
PHST- 2007/10/16 09:00 [pubmed]
PHST- 2007/11/10 09:00 [medline]
PHST- 2007/10/16 09:00 [entrez]
PHST- 2018/07/12 00:00 [pmc-release]
AID - GE-14-35 [pii]
AID - 10.3727/000000007783991772 [doi]
PST - ppublish
SO  - Gene Expr. 2007;14(1):35-46. doi: 10.3727/000000007783991772.