PMID- 17933755
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20161124
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 28
IP  - 21
DP  - 2007 Nov
TI  - Intracoronary administration of autologous adipose tissue-derived stem cells 
      improves left ventricular function, perfusion, and remodelling after acute 
      myocardial infarction.
PG  - 2667-77
AB  - AIMS: This study was designed to assess whether intracoronary application of 
      adipose tissue-derived stem cells (ADSCs) compared with bone marrow-derived stem 
      cells (BMSCs) and control could improve cardiac function after 30 days in a 
      porcine acute myocardial infarction/reperfusion model. METHODS AND RESULTS: An 
      acute transmural porcine myocardial infarction was induced by inflating an 
      angioplasty balloon for 180 min in the mid-left anterior descending artery. Two 
      million cultured autologous stem cells were intracoronary injected through the 
      central lumen of the inflated balloon catheter. Analysis of scintigraphic data 
      obtained after 28 +/- 3 days showed that both absolute and relative perfusion 
      defect decreased significantly after intracoronary administration of ADSCs or 
      BMSCs (relative 30 or 31%, respectively), compared with carrier administration 
      alone (12%, P = 0.048). Left ventricular ejection fraction after 4 weeks 
      increased significantly more after ADSC and BMSC administration than after 
      carrier administration: 11.39 +/- 4.62 and 9.59 +/- 7.95%, respectively vs. 1.95 
      +/- 4.7%, P = 0.02). The relative thickness of the ventricular wall in the 
      infarction area after cell administration was significantly greater than that 
      after carrier administration. The vascular density of the border zone also 
      improved. The grafted cells co-localized with von Willebrand factor and 
      alpha-smooth muscle actin and incorporated into newly formed vessels. CONCLUSION: 
      This is the first study to show that not only bone marrow-derived cells but also 
      ADSCs engrafted in the infarct region 4 weeks after intracoronary cell 
      transplantation and improved cardiac function and perfusion via angiogenesis.
FAU - Valina, Christian
AU  - Valina C
AD  - Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 
      70112, USA.
FAU - Pinkernell, Kai
AU  - Pinkernell K
FAU - Song, Yao-Hua
AU  - Song YH
FAU - Bai, Xiaowen
AU  - Bai X
FAU - Sadat, Sanga
AU  - Sadat S
FAU - Campeau, Richard J
AU  - Campeau RJ
FAU - Le Jemtel, Thierry H
AU  - Le Jemtel TH
FAU - Alt, Eckhard
AU  - Alt E
LA  - eng
GR  - 1P01HL076100/HL/NHLBI NIH HHS/United States
GR  - 1R01NS044832/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071011
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
CIN - Eur Heart J. 2007 Nov;28(21):2565-7. PMID: 17933758
MH  - Adipocytes/diagnostic imaging/*transplantation
MH  - Angioplasty, Balloon, Coronary/methods
MH  - Animals
MH  - Bone Marrow Transplantation/*methods
MH  - Cardiac Catheterization/methods
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Myocardial Infarction/diagnostic imaging/*therapy
MH  - Myocardial Reperfusion/methods
MH  - Radionuclide Imaging
MH  - Random Allocation
MH  - Stroke Volume/physiology
MH  - Swine
MH  - Ventricular Remodeling/*physiology
EDAT- 2007/10/16 09:00
MHDA- 2008/06/20 09:00
CRDT- 2007/10/16 09:00
PHST- 2007/10/16 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2007/10/16 09:00 [entrez]
AID - ehm426 [pii]
AID - 10.1093/eurheartj/ehm426 [doi]
PST - ppublish
SO  - Eur Heart J. 2007 Nov;28(21):2667-77. doi: 10.1093/eurheartj/ehm426. Epub 2007 
      Oct 11.