PMID- 17935861
OWN - NLM
STAT- MEDLINE
DCOM- 20080722
LR  - 20211020
IS  - 0301-5629 (Print)
IS  - 0301-5629 (Linking)
VI  - 34
IP  - 2
DP  - 2008 Feb
TI  - Remote temperature estimation in intravascular photoacoustic imaging.
PG  - 299-308
AB  - Intravascular photoacoustic (IVPA) imaging is based on the detection of 
      laser-induced acoustic waves generated within the arterial tissue under pulsed 
      laser irradiation. In general, laser radiant energy levels are kept low (20 
      mJ/cm(2)) during photoacoustic imaging to conform to general standards for safe 
      use of lasers on biological tissues. However, safety standards in intravascular 
      photoacoustic imaging are not yet fully established. Consequently, monitoring 
      spatio-temporal temperature changes associated with laser-tissue interaction is 
      important to address thermal safety of IVPA imaging. In this study we utilize the 
      IVUS-based strain measurements to estimate the laser-induced temperature 
      increase. Temporal changes in temperature were estimated in a phantom modeling a 
      vessel with an inclusion. A cross-correlation-based time delay estimator was used 
      to assess temperature-induced strains produced by different laser radiant 
      energies. The IVUS-based remote measurements revealed temperature increases of 
      0.7+/-0.3 degrees C, 2.9+/-0.2 degrees C and 5.0+/-0.2 degrees C, for the laser 
      radiant energies of 30 mJ/cm(2), 60 mJ/cm(2) and 85 mJ/cm(2), respectively. The 
      technique was then used in imaging of ex vivo samples of a normal rabbit aorta. 
      For arterial tissues, a temperature elevation of 1.1 degrees C was observed for a 
      laser fluence of 60 mJ/cm(2) and lesser than 1 degrees C for lower energy levels 
      normally associated with IVPA imaging. Therefore, the developed ultrasound 
      technique can be used to monitor temperature during IVPA imaging. Furthermore, 
      the analysis based on the Arrhenius thermal damage model indicates no thermal 
      injury in the arterial tissue, suggesting the safety of IVPA imaging.
FAU - Sethuraman, Shriram
AU  - Sethuraman S
AD  - Department of Biomedical Engineering, The University of Texas at Austin, Austin, 
      TX 78712, USA.
FAU - Aglyamov, Salavat R
AU  - Aglyamov SR
FAU - Smalling, Richard W
AU  - Smalling RW
FAU - Emelianov, Stanislav Y
AU  - Emelianov SY
LA  - eng
GR  - R21 HL084076-01A2/HL/NHLBI NIH HHS/United States
GR  - R21 EB004963/EB/NIBIB NIH HHS/United States
GR  - R21 HL084076/HL/NHLBI NIH HHS/United States
GR  - EB004963/EB/NIBIB NIH HHS/United States
GR  - R21 EB004963-01A1/EB/NIBIB NIH HHS/United States
GR  - HL084076/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071023
PL  - England
TA  - Ultrasound Med Biol
JT  - Ultrasound in medicine & biology
JID - 0410553
SB  - IM
MH  - Animals
MH  - Aorta/diagnostic imaging
MH  - Lasers/*adverse effects
MH  - Phantoms, Imaging
MH  - Rabbits
MH  - Stress, Mechanical
MH  - *Temperature
MH  - Thermometers
MH  - Ultrasonography, Interventional/instrumentation/*methods
PMC - PMC2267933
MID - NIHMS40118
EDAT- 2007/10/16 09:00
MHDA- 2008/07/23 09:00
PMCR- 2008/03/17
CRDT- 2007/10/16 09:00
PHST- 2006/12/14 00:00 [received]
PHST- 2007/07/03 00:00 [revised]
PHST- 2007/07/31 00:00 [accepted]
PHST- 2007/10/16 09:00 [pubmed]
PHST- 2008/07/23 09:00 [medline]
PHST- 2007/10/16 09:00 [entrez]
PHST- 2008/03/17 00:00 [pmc-release]
AID - S0301-5629(07)00391-2 [pii]
AID - 10.1016/j.ultrasmedbio.2007.07.021 [doi]
PST - ppublish
SO  - Ultrasound Med Biol. 2008 Feb;34(2):299-308. doi: 
      10.1016/j.ultrasmedbio.2007.07.021. Epub 2007 Oct 23.