PMID- 17938409
OWN - NLM
STAT- MEDLINE
DCOM- 20071226
LR  - 20190702
IS  - 0042-4900 (Print)
IS  - 0042-4900 (Linking)
VI  - 161
IP  - 15
DP  - 2007 Oct 13
TI  - Infection dynamics of porcine reproductive and respiratory syndrome virus in a 
      continuous-flow population of pigs also infected with Mycoplasma hyopneumoniae.
PG  - 515-20
AB  - Twenty-eight 10-week-old pigs were inoculated intratracheally with 1 x 10(5) 
      colour-changing units/ml Mycoplasma hyopneumoniae strain 232, and another 32 pigs 
      were not inoculated but were divided into 12 direct-contact pigs and 20 
      indirect-contact pigs. Thirty-five days later, the inoculated pigs were 
      inoculated intranasally with 1 x 10(2.4) tcid50 of porcine reproductive and 
      respiratory syndrome virus (PRRSV) strain mn 30-100. Viraemia, seroconversion and 
      the transmission of PRRSV in the M hyopneumoniae-infected pigs were then assessed 
      for four months. Three groups of 10 age-matched gilts were introduced as 
      sentinels into the experimental barn on days 28, 56 and 84 after the PRRSV 
      infection. The persistence of PRRSV was evaluated in both the experimentally and 
      naturally infected pigs, which were slaughtered 120, 135 and 150 days after the 
      infection. The period of viraemia and the extent of seroconversion were similar 
      to those observed in studies of pigs infected only with PRRSV, suggesting that 
      under the conditions of the study M hyopneumoniae did not affect these features 
      of the disease. A delayed pattern in the seroconversion and proportion of 
      pcr-positive pigs was observed in the direct and indirect contact groups, and the 
      persistence of PRRSV in tissues was confirmed by pcr at 120 and 150 days after 
      infection only in the directly inoculated pigs and not in the direct- or 
      indirect-contact groups of pigs.
FAU - Fano, E
AU  - Fano E
AD  - Swine Disease Eradication Center, University of Minnesota College of Veterinary 
      Medicine, 385 Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St 
      Paul, MN 55108, USA.
FAU - Pijoan, C
AU  - Pijoan C
FAU - Dee, S
AU  - Dee S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (Viral Proteins)
RN  - 0 (glycoprotein 5, PRRSV)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/blood
MH  - Antibodies, Viral/blood
MH  - DNA, Viral/analysis
MH  - Female
MH  - Mycoplasma Infections/complications/pathology/*veterinary
MH  - Mycoplasma hyopneumoniae/isolation & purification/pathogenicity
MH  - Pneumonia of Swine, Mycoplasmal/*epidemiology/microbiology/transmission
MH  - Pneumonia, Bacterial/complications/pathology/*veterinary
MH  - Pneumonia, Viral/complications/pathology/*veterinary
MH  - Polymerase Chain Reaction/veterinary
MH  - Population Dynamics
MH  - Porcine Reproductive and Respiratory Syndrome/*epidemiology/transmission/virology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & purification
MH  - Random Allocation
MH  - Sentinel Surveillance/veterinary
MH  - Swine
MH  - Viral Envelope Proteins
MH  - Viral Proteins/genetics
EDAT- 2007/10/17 09:00
MHDA- 2007/12/27 09:00
CRDT- 2007/10/17 09:00
PHST- 2007/10/17 09:00 [pubmed]
PHST- 2007/12/27 09:00 [medline]
PHST- 2007/10/17 09:00 [entrez]
AID - 161/15/515 [pii]
AID - 10.1136/vr.161.15.515 [doi]
PST - ppublish
SO  - Vet Rec. 2007 Oct 13;161(15):515-20. doi: 10.1136/vr.161.15.515.