PMID- 17938645
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20081110
IS  - 1476-5608 (Electronic)
IS  - 1365-7852 (Linking)
VI  - 11
IP  - 4
DP  - 2008
TI  - HLA class II antigen presentation by prostate cancer cells.
PG  - 334-41
AB  - Prostate cancer is the second most commonly diagnosed cancer in men. Recent 
      evidence suggests that reduced expression of target protein antigens and human 
      leukocyte antigen (HLA) molecules is the predominant immune escape mechanism of 
      malignant prostate tumor cells. The purpose of this study was to investigate the 
      prospect of antigen specific immunotherapy against prostate cancer via the HLA 
      class II pathway of immune recognition. Here, we show for the first time that 
      prostate cancer cells express HLA class II proteins that are recognized by CD4+ T 
      cells. Prostate tumor cells transduced with class II molecules efficiently 
      presented tumor-associated antigens/peptides to CD4+ T cells. This data suggests 
      that malignant prostate tumors can be targeted via the HLA class II pathway, and 
      that class II-positive tumors could be employed for direct antigen presentation, 
      and CD4+ T-cell mediated tumor immunotherapy.Prostate Cancer and Prostatic 
      Diseases (2008) 11, 334-341; doi:10.1038/sj.pcan.4501021; published online 16 
      October 2007.
FAU - Younger, A R
AU  - Younger AR
AD  - Department of Microbiology and Immunology, Medical University of South Carolina, 
      Charleston, SC29425, USA.
FAU - Amria, S
AU  - Amria S
FAU - Jeffrey, W A
AU  - Jeffrey WA
FAU - Mahdy, A E M
AU  - Mahdy AE
FAU - Goldstein, O G
AU  - Goldstein OG
FAU - Norris, J S
AU  - Norris JS
FAU - Haque, A
AU  - Haque A
LA  - eng
GR  - P01 CA97132/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071016
PL  - England
TA  - Prostate Cancer Prostatic Dis
JT  - Prostate cancer and prostatic diseases
JID - 9815755
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Cell Culture Techniques
MH  - Cell Line, Tumor
MH  - Cell Membrane/immunology
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Male
MH  - Prostatic Neoplasms/*immunology
MH  - T-Lymphocytes/immunology
EDAT- 2007/10/17 09:00
MHDA- 2009/01/15 09:00
CRDT- 2007/10/17 09:00
PHST- 2007/10/17 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
PHST- 2007/10/17 09:00 [entrez]
AID - 4501021 [pii]
AID - 10.1038/sj.pcan.4501021 [doi]
PST - ppublish
SO  - Prostate Cancer Prostatic Dis. 2008;11(4):334-41. doi: 10.1038/sj.pcan.4501021. 
      Epub 2007 Oct 16.