PMID- 17939142
OWN - NLM
STAT- MEDLINE
DCOM- 20071128
LR  - 20071024
IS  - 1365-2168 (Electronic)
IS  - 0007-1323 (Linking)
VI  - 94
IP  - 11
DP  - 2007 Nov
TI  - Management of sporadic and multiple endocrine neoplasia type 1 gastrinomas.
PG  - 1331-41
AB  - BACKGROUND: Gastrinomas are functional endocrine duodenopancreatic tumours and 
      are responsible for Zollinger-Ellison syndrome (ZES). Clinical presentation, 
      localization techniques and operative management were reviewed. METHODS: An 
      electronic search of the Medline database was undertaken for articles published 
      in English between January 1987 and May 2007. This timeframe was chosen because 
      of the fundamental changes in operative strategy, antisecretory therapy and 
      localization techniques during this period. RESULTS AND CONCLUSION: Most 
      gastrinomas are located in the 'gastrinoma triangle', comprising the head of the 
      pancreas, and the first and second parts of the duodenum. Some 20 per cent of 
      gastrinomas occur in association with multiple endocrine neoplasia type 1 (MEN1) 
      and 50-60 per cent of tumours are malignant at the time of diagnosis. Biochemical 
      evidence justifies operation of which duodenotomy is an essential part. Only 
      complete tumour resection allows 5- and 10-year survival rates of 90 per cent. 
      Pylorus-preserving pancreaticoduodenectomy may be the procedure of choice for 
      MEN1-ZES.
CI  - Copyright (c) 2007 British Journal of Surgery Society Ltd.
FAU - Fendrich, V
AU  - Fendrich V
AD  - Department of Surgery, Philipps University Marburg, Marburg, Bielefeld, Germany. 
      fendrich@med.uni-marburg.de
FAU - Langer, P
AU  - Langer P
FAU - Waldmann, J
AU  - Waldmann J
FAU - Bartsch, D K
AU  - Bartsch DK
FAU - Rothmund, M
AU  - Rothmund M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
SB  - IM
MH  - Duodenal Neoplasms/genetics/*therapy
MH  - Gastrinoma/genetics/*surgery
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*therapy
MH  - Pancreatic Neoplasms/genetics/*therapy
MH  - Prognosis
RF  - 96
EDAT- 2007/10/17 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/10/17 09:00
PHST- 2007/10/17 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/10/17 09:00 [entrez]
AID - 10.1002/bjs.5987 [doi]
PST - ppublish
SO  - Br J Surg. 2007 Nov;94(11):1331-41. doi: 10.1002/bjs.5987.