PMID- 17939547
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20190513
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 21
IP  - 5
DP  - 2007 Sep-Oct
TI  - Azotemia and glomerular filtration rate in dogs with chronic valvular disease.
PG  - 943-9
AB  - BACKGROUND: Little information is available about the prevalence of renal 
      dysfunction in dogs with chronic valvular heart disease (CVD). HYPOTHESIS: 
      Azotemia and a decrease in glomerular filtration rate (GFR) are more severe with 
      increased severity of CVD. ANIMALS: 124 (study No. 1) and 24 (study No. 2) 
      client-owned dogs with CVD. METHODS: A retrospective study (study No. 1) was 
      performed to assess the prevalence of azotemia in the New York Heart Association 
      (NYHA) classes of heart failure in dogs with CVD. A prospective study (study No. 
      2) was then designed to determine GFR in dogs with different degrees of CVD 
      severity. Complete physical examination, electrocardiography, blood pressure 
      measurement, thoracic radiographs, echocardiography, and plasma and urine 
      analyses were also performed. RESULTS: In study No. 1, 50% of the dogs were 
      azotemic and the percentage of azotemic dogs increased with functional class (up 
      to 70% in NYHA class IV patients). In study No. 2, 8/24 dogs were azotemic. 
      Plasma urea and creatinine were higher in NYHA class III-IV dogs compared with 
      class I-II dogs. The GFR was lower (P < .001) in NYHA class III-IV dogs (1.7 +/- 
      0.7 mL/min/kg) than in class I to II dogs (3.1 +/- 0.8 mL/min/kg). Only 1 dog in 
      class I-II had a GFR below 2 mL/min/kg and only 2/9 class III-IV dogs had a GFR 
      above 2 mL/min/kg. CONCLUSION AND CLINICAL RELEVANCE: Azotemia and renal 
      impairment increase with the severity of congestive heart failure and are 
      frequent findings in dogs with CVD. It remains to be shown if deterioration of 
      renal function is a direct result of progression of the heart disease.
FAU - Nicolle, Audrey P
AU  - Nicolle AP
AD  - Unite de Cardiologie d'Alfort and INSERM U660, National Veterinary School, 7 
      Avenue du General de Gaulle, F94704 Maisons-Alfort Cedex, France.
FAU - Chetboul, Valerie
AU  - Chetboul V
FAU - Allerheiligen, Till
AU  - Allerheiligen T
FAU - Pouchelon, Jean-Louis
AU  - Pouchelon JL
FAU - Gouni, Vassiliki
AU  - Gouni V
FAU - Tessier-Vetzel, Dominique
AU  - Tessier-Vetzel D
FAU - Sampedrano, Carolina Carlos
AU  - Sampedrano CC
FAU - Lefebvre, Herve P
AU  - Lefebvre HP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 8W8T17847W (Urea)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Azotemia/complications/physiopathology/*veterinary
MH  - Blood Chemical Analysis/veterinary
MH  - Blood Pressure/physiology
MH  - Blood Urea Nitrogen
MH  - Cardiovascular Diseases/complications/physiopathology/*veterinary
MH  - Creatinine/blood
MH  - Dog Diseases/*physiopathology
MH  - Dogs
MH  - Echocardiography, Doppler/veterinary
MH  - Female
MH  - Glomerular Filtration Rate/physiology/*veterinary
MH  - Male
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Urea/blood
EDAT- 2007/10/18 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/10/18 09:00
PHST- 2007/10/18 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/10/18 09:00 [entrez]
AID - 10.1892/0891-6640(2007)21[943:aagfri]2.0.co;2 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2007 Sep-Oct;21(5):943-9. doi: 
      10.1892/0891-6640(2007)21[943:aagfri]2.0.co;2.