PMID- 17940698
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20071017
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 59
IP  - 5
DP  - 2007 Oct 25
TI  - Immunoregulatory effects of homocysteine on cardiovascular diseases.
PG  - 585-92
AB  - Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for 
      atherosclerosis for more than 30 years, but the mechanisms by which HHcy leads to 
      atherosclerosis are not well fully understood. In this review, we will summarize 
      the immunoregulatory effects of homocysteine on cardiovascular diseases from 
      humoral immunity, monocyte/macrophage and T lymphocyte activity. Homocysteine can 
      induce chemokine and cytokine secretion in monocytes and T lymphocytes and also 
      directly stimulate B lymphocyte proliferation and IgG secretion. In addition, the 
      cellular mechanisms that may explain the pro-inflammatory effect of HHcy are 
      included. Homocysteine may directly or indirectly lead to oxidative stress or 
      endoplasmic reticulum (ER) stress. Elevated levels of homocysteine also decrease 
      the bioavailability of nitric oxide and modulate the levels of other metabolites 
      including S-adenosyl methionine and S-adenosyl homocysteine which may result in 
      cardiovascular diseases.
FAU - Dai, Jing
AU  - Dai J
AD  - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, 
      Peking University, Beijing 100083, China.
FAU - Wang, Xian
AU  - Wang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - Homocysteinemia
SB  - IM
MH  - Animals
MH  - Atherosclerosis
MH  - Cardiovascular Diseases/immunology/*physiopathology
MH  - Homocysteine/*physiology
MH  - Humans
MH  - Hyperhomocysteinemia/complications
MH  - Macrophages
MH  - Nitric Oxide
MH  - Oxidative Stress
EDAT- 2007/10/18 09:00
MHDA- 2014/09/30 06:00
CRDT- 2007/10/18 09:00
PHST- 2007/10/18 09:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
PHST- 2007/10/18 09:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 2007 Oct 25;59(5):585-92.