PMID- 17940858
OWN - NLM
STAT- MEDLINE
DCOM- 20080219
LR  - 20211020
IS  - 1383-875X (Print)
IS  - 1383-875X (Linking)
VI  - 20
IP  - 1-2
DP  - 2007 Nov
TI  - Reversal of dilated cardiomyopathy by the elimination of frequent left or right 
      premature ventricular contractions.
PG  - 9-13
AB  - BACKGROUND: RF ablation of frequent premature ventricular contractions (PVC) has 
      recently been shown to improve left ventricular (LV) systolic function and 
      dimensions in a few patients, however mainly when they originated from the right 
      ventricular outflow tract. METHODS: RF ablation was performed at various 
      ventricular locations in six consecutive patients with frequent, isolated PVC 
      associated with idiopathic dilated cardiomyopathy (DCM). Baseline clinical 
      status, PVC counts, LV ejection fraction (EF) and end-diastolic diameter (EDD) 
      were recorded at baseline and at 6 months of follow-up. RESULTS: PVC ablation was 
      performed in the right ventricle in four patients, the left ventricle in two 
      patients. Before RF ablation, five patients were in New York Heart Association 
      (NYHA) functional class I, and one patient was in class II. After RF ablation, 
      the mean PVC count/24 h decreased from 17,717 +/- 7,100 to 268 +/- 366 (p = 
      0.006) while LVEF increased from 42 +/- 2.5% to 57 +/- 3% (p = 0.0001) and LVEDD 
      decreased from 60.0 +/- 3.5 to 54.0 +/- 3.7 mm (p = 0.0009). The clinical status 
      normalized with regression of palpitations and NYHA class. CONCLUSIONS: 
      Elimination of frequent isolated PVC in patients with DCM with RF can normalize 
      the clinical status and LV systolic function and dimensions, regardless of the 
      morphology or origin of the PVC.
FAU - Taieb, Jerome M
AU  - Taieb JM
AD  - Cardiology, Hospital Center of Aix en Provence, Avenue des Tamaris, Aix en 
      Provence, 13616, France. taiebj@free.fr
FAU - Maury, Philippe
AU  - Maury P
FAU - Shah, Dipen
AU  - Shah D
FAU - Duparc, Alexandre
AU  - Duparc A
FAU - Galinier, Michel
AU  - Galinier M
FAU - Delay, Marc
AU  - Delay M
FAU - Morice, Ronan
AU  - Morice R
FAU - Alfares, Ali
AU  - Alfares A
FAU - Barnay, Claude
AU  - Barnay C
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20071017
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Cardiomyopathy, Dilated/*complications/*surgery
MH  - Catheter Ablation/*methods
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Secondary Prevention
MH  - Treatment Outcome
MH  - Ventricular Premature Complexes/*etiology/*prevention & control
EDAT- 2007/10/18 09:00
MHDA- 2008/02/20 09:00
CRDT- 2007/10/18 09:00
PHST- 2007/06/27 00:00 [received]
PHST- 2007/08/13 00:00 [accepted]
PHST- 2007/10/18 09:00 [pubmed]
PHST- 2008/02/20 09:00 [medline]
PHST- 2007/10/18 09:00 [entrez]
AID - 10.1007/s10840-007-9157-2 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2007 Nov;20(1-2):9-13. doi: 
      10.1007/s10840-007-9157-2. Epub 2007 Oct 17.