PMID- 17940915
OWN - NLM
STAT- MEDLINE
DCOM- 20071121
LR  - 20211020
IS  - 1559-7105 (Print)
IS  - 1559-7113 (Electronic)
IS  - 1559-7105 (Linking)
VI  - 35
IP  - 1
DP  - 2006 Feb
TI  - Requirement of TrkB for synapse elimination in developing cerebellar Purkinje 
      cells.
PG  - 87-101
AB  - The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic 
      factor (BDNF) and neurotrophin-4/5 (NT-4/5), are critically important for growth, 
      survival and activity-dependent synaptic strengthening in the central nervous 
      system. These TrkB-mediated actions occur in a highly cell-type specific manner. 
      Here we report that cerebellar Purkinje cells, which are richly endowed with TrkB 
      receptors, develop a normal morphology in trkB-deficient mice. Thus, in contrast 
      to other types of neurons, Purkinje cells do not need TrkB for dendritic growth 
      and spine formation. Instead, we find a moderate delay in the maturation of 
      GABAergic synapses and, more importantly, an abnormal multiple climbing fiber 
      innervation in Purkinje cells in trkB-deficient mice. Thus, our results 
      demonstrate an involvement of TrkB receptors in synapse elimination and reveal a 
      new role for receptor tyrosine kinases in the brain.
FAU - Bosman, Laurens W J
AU  - Bosman LW
AD  - Institut fur Neurowissenschaften, Technische Universitat Munchen, Biedersteiner 
      Strasse 29, 80802, Munchen, Germany.
FAU - Hartmann, Jana
AU  - Hartmann J
FAU - Barski, Jaroslaw J
AU  - Barski JJ
FAU - Lepier, Alexandra
AU  - Lepier A
FAU - Noll-Hussong, Michael
AU  - Noll-Hussong M
FAU - Reichardt, Louis F
AU  - Reichardt LF
FAU - Konnerth, Arthur
AU  - Konnerth A
LA  - eng
GR  - P01 NS016033/NS/NINDS NIH HHS/United States
GR  - P01 NS016033-250014/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070301
PL  - United States
TA  - Brain Cell Biol
JT  - Brain cell biology
JID - 101272887
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Shape/physiology
MH  - Dendrites/physiology/ultrastructure
MH  - Dendritic Spines/physiology
MH  - Inhibitory Postsynaptic Potentials/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Mice, Mutant Strains
MH  - Purkinje Cells/*cytology/*physiology/ultrastructure
MH  - Receptor, trkB/genetics/*metabolism
MH  - Synapses/*physiology
MH  - gamma-Aminobutyric Acid/physiology
PMC - PMC3303929
MID - NIHMS111500
EDAT- 2007/10/18 09:00
MHDA- 2007/12/06 09:00
PMCR- 2012/03/15
CRDT- 2007/10/18 09:00
PHST- 2006/08/11 00:00 [received]
PHST- 2006/11/15 00:00 [accepted]
PHST- 2006/11/14 00:00 [revised]
PHST- 2007/10/18 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/10/18 09:00 [entrez]
PHST- 2012/03/15 00:00 [pmc-release]
AID - 10.1007/s11068-006-9002-z [doi]
PST - ppublish
SO  - Brain Cell Biol. 2006 Feb;35(1):87-101. doi: 10.1007/s11068-006-9002-z. Epub 2007 
      Mar 1.