PMID- 17942328
OWN - NLM
STAT- MEDLINE
DCOM- 20080616
LR  - 20220318
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Print)
IS  - 1074-7427 (Linking)
VI  - 89
IP  - 3
DP  - 2008 Mar
TI  - BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
PG  - 312-23
AB  - It is generally believed that late-phase long-term potentiation (L-LTP) and 
      long-term memory (LTM) require new protein synthesis. Although the full 
      complement of proteins mediating the long-lasting changes in synaptic efficacy 
      have yet to be identified, several lines of evidence point to a crucial role for 
      activity-induced brain-derived neurotrophic factor (BDNF) expression in 
      generating sustained structural and functional changes at hippocampal synapses 
      thought to underlie some forms of LTM. In particular, BDNF is sufficient to 
      induce the transformation of early to late-phase LTP in the presence of protein 
      synthesis inhibitors, and inhibition of BDNF signaling impairs LTM. Despite solid 
      evidence for a critical role of BDNF in L-LTP and LTM, many issues are not 
      resolved. Given that BDNF needs to be processed in Golgi outposts localized at 
      the branch point of one or few dendrites, a conceptually challenging problem is 
      how locally synthesized BDNF in dendrites could ensure synapse-specific 
      modulation of L-LTP. An interesting alternative is that BDNF-TrkB signaling is 
      involved in synaptic tagging, a prominent hypothesis that explains how 
      soma-derived protein could selectively modulate the tetanized (tagged) synapse. 
      Finally, specific roles of BDNF in the acquisition, retention or extinction of 
      LTM remain to be established.
FAU - Lu, Yuan
AU  - Lu Y
AD  - Gene, Cognition and Psychosis Program (GCAP), NIMH, National Institutes of 
      Health, Bethesda, MD 20892-3714, USA.
FAU - Christian, Kimberly
AU  - Christian K
FAU - Lu, Bai
AU  - Lu B
LA  - eng
GR  - NIH0011553913/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20071017
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dendrites/metabolism
MH  - Extinction, Biological
MH  - Genes, Regulator/*genetics
MH  - Hippocampus/drug effects/metabolism
MH  - Humans
MH  - Long-Term Potentiation/*physiology
MH  - Long-Term Synaptic Depression/physiology
MH  - Memory/*physiology
MH  - Neuronal Plasticity/physiology
MH  - Polyribosomes/genetics
MH  - Protein Biosynthesis/*physiology
MH  - Retention, Psychology
MH  - Signal Transduction/physiology
MH  - Synapses/metabolism
PMC - PMC2387254
MID - NIHMS43783
EDAT- 2007/10/19 09:00
MHDA- 2008/06/17 09:00
PMCR- 2009/03/01
CRDT- 2007/10/19 09:00
PHST- 2007/08/12 00:00 [received]
PHST- 2007/08/23 00:00 [revised]
PHST- 2007/08/23 00:00 [accepted]
PHST- 2007/10/19 09:00 [pubmed]
PHST- 2008/06/17 09:00 [medline]
PHST- 2007/10/19 09:00 [entrez]
PHST- 2009/03/01 00:00 [pmc-release]
AID - S1074-7427(07)00140-2 [pii]
AID - 10.1016/j.nlm.2007.08.018 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2008 Mar;89(3):312-23. doi: 10.1016/j.nlm.2007.08.018. Epub 
      2007 Oct 17.